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Flexible sensors for detecting biomarkers with non-invasive procedures

Grant number: 17/26666-6
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): August 01, 2018
Effective date (End): July 31, 2019
Field of knowledge:Physical Sciences and Mathematics - Physics - Condensed Matter Physics
Principal Investigator:Osvaldo Novais de Oliveira Junior
Grantee:Paulo Augusto Raymundo Pereira
Supervisor: Joseph Wang
Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Research place: University of California, San Diego (UC San Diego), United States  
Associated to the scholarship:16/01919-6 - Design and fabrication of nanostructured flexible devices for biomarkers detection, BP.PD


This Project is aimed at developing flexible devices made of gold or platinum obtained via photolithography on polyethylene terephthalate (PET). These nanostructured flexible surfaces will be characterized by electrochemical techniques (cyclic voltammetry, electrochemical impedance spectroscopy), and be used to detect biomarkers, in addition to uric acid, ascorbic acid, dopamine and NADH in non-invasive procedures. The devices will also be coated with self-assembed monolayers (SAMs - mercaptoacetic acid and 11-mercaptoundecanoic) to prepare the surface for immobilization of biomolecules, such as enzymes and/or antibodies. This coating will be analyzed using electrochemical techniques (voltammetry, amperometry, electrochemical impedance spectroscopy). The biosensors will then be employed for detecting lactate and cholesterol in sweat by applying the flexible devices directly onto the skin during physical activities, while detection of glucose and cortisol will be performed in saliva, thus avoiding invasive methods.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SEMPIONATTO, JULIANE R.; RAYMUNDO-PEREIRA, PAULO A.; AZEREDO, NATHALIA F. B.; DE LOYOLA E SILVA, ANDRE N.; ANGNES, LUCIO; WANG, JOSEPH. Enzymatic biofuel cells based on protective hydrophobic carbon paste electrodes: towards epidermal bioenergy harvesting in the acidic sweat environment. CHEMICAL COMMUNICATIONS, v. 56, n. 13, p. 2004-2007, . (17/26666-6)

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