Proteome from the transition from colostrum to milk in goats: protein interactions for the maturation of the immune and digestive systems of the newborn

• Grant number: 17/22041-1
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: May 01, 2018
• End date: October 01, 2020
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Francisco Leydson Formiga Feitosa
• Grantee: Dielson da Silva Vieira
• Host Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil
• Associated scholarship(s): 19/02781-6 - Evaluation of protein profile based on intestinal and immunological development in goats and dairy cows, BE.EP.DR

Abstract

Dairy production in Brazil is an important part of the country's economy, and it is necessary to understand the physiology of the levels of production of the species involved in this cycle, in order to improve aspects of disease prevention and treatment. Colostrum is a key part in the formation of neonatal immunity, and its transition to milk in goats has not yet been fully elucidated when it comes to proteome and interactoma, which could help in the future both to ensure the transfer of immunity to newborns. In the early diagnosis of diseases such as Mastitis. Thus, the objective of this work is to determine the proteins presented from colostrum to milk after calving, in addition to comparing if there is difference between species of goats, other species and the correlation with diseases such as AVEC and Mastitis. The study will be conducted in the large animal sector of UNESP/FMVA and in a dairy goat farm. The proteome and interactoma analyzes will be performed following the methodologies proposed in this work according to some research groups. The results presented may provide new insights into the in vivo epithelial response after delivery, as well as pave the way for the discovery of protein biomarkers for monitoring both immunity transfer deficits, diseases such as AVEC, as well as early diagnosis of diseases such as Mamitis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VIEIRA, DIELSON DA S.; POLVEIRO, RICHARD C.; BUTLER, THOMAS J.; HACKETT, TIMOTHY A.; BRAGA, CAMILA P.; PUNIYA, BHANWAR LAL; TEIXEIRA, WESLEN F. P.; PADILHA, PEDRO DE M.; ADAMEC, JIRI; FEITOSA, FRANCISCO L. F.. An in silico, structural, and biological analysis of lactoferrin of different mammals. International Journal of Biological Macromolecules, v. 187, p. 119-126, SEP 30 2021. (17/22041-1, 19/02781-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

VIEIRA, Dielson da Silva. Transition from colostrum to goat's milk: new horizons in studies of proteins to metabolites.. 2020. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária. Araçatuba Araçatuba.