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Development of microfluidic device for monitoring circulating tumor cells

Grant number: 17/25937-6
Support type:Scholarships abroad - Research
Effective date (Start): August 01, 2018
Effective date (End): July 31, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal researcher:Valber de Albuquerque Pedrosa
Grantee:Valber de Albuquerque Pedrosa
Host: Z. Hugh Fan
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Research place: University of Florida, Gainesville (UF), United States  

Abstract

A typical tumor contains millions of cells that has genetic mutations leading them to grow, divide and invade healthy local tissue. However, as the cells proliferate, not all are located in the same space. Some cells separate from the borders of a tumor and they are carried by the blood or lymphatic system. Recently, monitoring of these cells known as circulating tumor cells has increased interest in the biomedical and health areas as they transmit a wide variety of chemical and biological signals that can produce a preventive clinical diagnosis. Therefore, the focus of this project is the development of microfluidic devices integrated with specific aptamers to study circulating prostate cancer cell tumor cells in blood and urine samples. We will use specific aptamers for prostate-specific membrane antigen (PSMA) and Prostate Cancer Gene 3 (PCA3) in a device where the cellular microenvironment can be precisely defined by providing new perspectives on the molecular events of metabolism and clinical analysis of patients invasive and accurate. (AU)

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