Salivary protein markers of radiation-related oral toxicites

• Grant number: 18/04657-8
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: June 01, 2018
• End date: January 31, 2021
• Field of knowledge: Health Sciences - Dentistry
• Principal Investigator: Alan Roger dos Santos Silva
• Grantee: Natália Rangel Palmier
• Host Institution: Faculdade de Odontologia de Piracicaba (FOP). Universidade Estadual de Campinas (UNICAMP). Piracicaba , SP, Brazil

Abstract

Aims: Lately there's been a great search for customized treatments regarding the molecular profile of diseases in order to increase treatment success rates and decrease long term morbidity rates. Thus, the present study aims to characterize the salivary proteomic profile of patients treated for head and neck cancer (HNC) aiming to correlate the proteomic profile results with the risk of developing oral toxicities of radiotherapy (RT) as well as the correlation with the severity. Patients and Methods: 50 patients diagnosed with OSCC that will initiate curative protocols of adjuvant radiotherapy (RT) or chemoradiotherapy (CRT), will be prospectively assessed. Acute toxicities will be daily evaluated during radiotherapy and in the dental follow-up visits 1 and 3 months after the end of RT (D+30 and D+90, respectively). For the chronic toxicities additional assessments will be performed on a quarterly basis according to the post-RT follow-up protocol of ICESP / FMUSP. Dysphagia, dysgeusia, mucositis, and osteoradionecrosis will be classified according to the Common Toxicity Criteria for Adverse Events (NCI, Version 4.0, 2010). Xerostomia will be assessed according to the scale adapted from Eisbruch et al., 2003. Radiation-related caries (RRC) will be classified according to the Post Radiation Dental Index (Walker et al., 2008). For the molecular analysis, whole saliva will be collected in 4 different times for acute toxicities (D-1, D30, D+30RT and D+90) and 7 times for chronic toxicity (additional collections D+180; D+270; D+360) followed by proteomic analysis with mass spectrometry (MS / MS). Expected results: Characterize biomarkers that allow the identification of patients that are more likely to develop severe oral toxicities of the HNRT.

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PAGLIONI, MARIANA DE PAULI; DAMACENO ARAUJO, ANNA LUIZA; ARISTIZABAL ARBOLEDA, LADY PAOLA; PALMIER, NATALIA RANGEL; FONSECA, JESSICA MONTENEGRO; GOMES-SILVA, WAGNER; CAMILO MADRID-TROCONIS, CRISTHIAN; SILVEIRA, FELIPE MARTINS; MARTINS, MANOELA DOMINGUES; FARIA, KARINA MORAIS; et al. Tumor safety and side effects of photobiomodulation therapy used for prevention and management of cancer treatment toxicities. A systematic review. Oral Oncology, v. 93, p. 21-28, JUN 2019. (18/04657-8, 18/02233-6)

PALMIER, NATALIA RANGEL; MADRID TROCONIS, CRISTHIAN CAMILO; COSTA NORMANDO, ANA GABRIELA; SILVA GUERRA, ELIETE NEVES; DAMACENO ARAUJO, ANNA LUIZA; ARISTIZABAL ARBOLEDA, LADY PAOLA; FONSECA, JESSICA MONTENEGRO; PAGLIONI, MARIANA DE PAULI; GOMES-SILVA, WAGNER; VECHIATO FILHO, ALJOMAR JOSE; et al. Impact of head and neck radiotherapy on the longevity of dental adhesive restorations: A systematic review and meta-analysis. JOURNAL OF PROSTHETIC DENTISTRY, v. 128, n. 5, p. 11-pg., 2022-11-30. (12/06138-1, 18/02233-6, 16/22862-2, 18/04657-8, 13/18402-8)

PALMIER, NATALIA RANGEL; PAES LEME, ADRIANA FRANCO; DE ROSSI, TATIANE; TELLES, GUILHERME PIMENTEL; MORAIS-FARIA, KARINA; KOWALSKI, LUIZ PAULO; MARTA, GUSTAVO NADER; BRANDAO, THAIS BIANCA; ARANY, PRAVEEN R.; MIGLIORATI, CESAR AUGUSTO; et al. Salivary alpha-1-antitrypsin and macrophage migration inhibitory factor may be potential prognostic biomarkers for oncologic treatment-induced severe oral mucositis. SUPPORTIVE CARE IN CANCER, v. 29, n. 6, p. 2939-2946, JUN 2021. (18/04657-8, 15/12431-1, 12/06138-1, 13/18402-8, 16/22862-2, 16/07846-0, 18/02233-6)

GOUVEA VASCONCELLOS, ADRIELE FERREIRA; PALMIER, NATALIA RANGEL; RIBEIRO, ANA CAROLINA PRADO; NORMANDO, ANA GABRIELA COSTA; MORAIS-FARIA, KARINA; GOMES-SILVA, WAGNER; VECHIATO FILHO, ALJOMAR JOSE; DE GOES, MARIO FERNANDO; PAES LEME, ADRIANA FRANCO; BRANDAO, THAIS BIANCA; et al. Impact of Clustering Oral Symptoms in the Pathogenesis of Radiation Caries: A Systematic Review. Caries Research, v. 54, n. 2, p. 113-126, AUG 2020. (18/02233-6, 18/04657-8, 13/18402-8)

PALMIER, NATALIA RANGEL; PRADO-RIBEIRO, ANA CAROLINA; MARIZ, BRUNO AUGUSTO LINHARES ALMEIDA; RODRIGUES-OLIVEIRA, LETICIA; PAGLIONI, MARIANA DE PAULI; NAPIMOGA, JULIANA TRINDADE CLEMENTE; PEDROSO, CAIQUE MARIANO; MORAIS-FARIA, KARINA; DE OLIVEIRA, MARIA CECILIA QUERIDO; VECHIATO-FILHO, ALJOMAR JOSE; et al. The impact of radiation caries on morbidity and mortality outcomes of head and neck squamous cell carcinoma patients. SPECIAL CARE IN DENTISTRY, v. N/A, p. 12-pg., 2023-03-05. (18/04657-8, 12/06138-1, 18/02233-6, 13/18402-8, 16/22862-2)

MARTINS, BEATRIZ NASCIMENTO FIGUEIREDO LEBRE; PALMIER, NATALIA RANGEL; PRADO-RIBEIRO, ANA CAROLINA; DE GOES, MARIO FERNANDO; LOPES, MARCIO AJUDARTE; BRANDA, THAIS BIANCA; RIVERA, CESAR; MIGLIORATI, CESAR AUGUSTO; EPSTEIN, JOEL B.; SANTOS-SILVA, ALAN ROGER. Awareness of the risk of radiation-related caries in patients with head and neck cancer: A survey of physicians, dentists, and patients. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v. 132, n. 4, p. 398-408, OCT 2021. (16/22862-2, 13/18402-8, 12/06138-1, 18/04657-8, 18/02233-6)

PAGLIONI, MARIANA DE PAULI; FARIA, KARINA MORAIS; PALMIER, NATALIA RANGEL; PRADO-RIBEIRO, ANA CAROLINA; BRITO E DIAS, REINALDO; DA GRACA PINTO, HENRIQUE; TREISTER, NATHANIEL SIMON; EPSTEIN, JOEL B.; MIGLIORATI, CESAR AUGUSTO; SANTOS-SILVA, ALAN ROGER; et al. Patterns of oral mucositis in advanced oral squamous cell carcinoma patients managed with prophylactic photobiomodulation therapy-insights for future protocol development. Lasers in Medical Science, v. 36, n. 2, JUL 2020. (12/06138-1, 13/18402-8, 18/04657-8, 18/02233-6)

PALMIER, NATALIA RANGEL; MIGLIORATI, CESAR AUGUSTO; PRADO-RIBEIRO, ANA CAROLINA; QUERIDO DE OLIVEIRA, MARIA CECILIA; VECHIATO FILHO, ALJOMAR JOSE; DE GOES, MARIO FERNANDO; BRANDAO, THAIS BIANCA; LOPES, MARCIO AJUDARTE; SANTOS-SILVA, ALAN ROGER. Radiation-related caries: current diagnostic, prognostic, and management paradigms. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v. 130, n. 1, p. 52-62, JUL 2020. (18/02233-6, 12/06138-1, 13/18402-8, 16/22862-2, 18/04657-8)

MORAIS-FARIA, KARINA; PALMIER, NATALIA RANGEL; CORREIA, JAQUELINE DE LIMA; DE CASTRO JUNIOR, GILBERTO; DIAS, REINALDO BRITO; PINTO, HENRIQUE DA GRACA; LOPES, MARCIO AJUDARTE; PRADO RIBEIRO, ANA CAROLINA; BRANDAO, THAIS BIANCA; SANTOS-SILVA, ALAN ROGER. Young head and neck cancer patients are at increased risk of developing oral mucositis and trismus. SUPPORTIVE CARE IN CANCER, v. 28, n. 9, p. 4345-4352, SEP 2020. (18/02233-6, 16/22862-2, 18/04657-8)

PAGLIONI, MARIANA DE PAULI; KHURRAM, SYED ALI; RUIZ, BLANCA ICIAR INDAVE; LAUBY-SECRETAN, BEATRICE; NORMANDO, ANA GABRIELA; PRADO RIBEIRO, ANA CAROLINA; BRANDAO, THAIS BIANCA; PALMIER, NATALIA RANGEL; LOPES, MARCIO AJUDARTE; DA SILVA GUERRA, ELIETE NEVES; et al. Clinical predictors of malignant transformation and recurrence in oral potentially malignant disorders: A systematic review and meta-analysis. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, v. 134, n. 5, p. 15-pg., 2022-11-28. (18/04657-8, 12/06138-1, 18/02233-6, 13/18402-8, 16/22862-2)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PALMIER, Natália Rangel. New perspectives of clinical features and salivary protein biomarkers of radiation induced oral toxicities. 2021. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Odontologia de Piracicaba Piracicaba, SP.