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Study on tick relapsing fever group spirochetes (Spirochaetaceae: Borrelia) on ticks of genus Ornithodoros (Acari: Argasidae) parasitizing humans in Brazil

Grant number: 18/02521-1
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): July 01, 2018
Effective date (End): December 05, 2019
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine
Principal researcher:Marcelo Bahia Labruna
Grantee:Sebastián Alejandro Munoz Leal
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):19/17960-3 - Advanced culture techniques, next generation sequencing, and immunoblot applied to the study of a Brazilian relapsing fever spirochete, BE.EP.PD

Abstract

Ticks of Argasidae Family transmit bacterial microorganisms to vertebrate hosts that they parasitize, including humans. Particularly, antropophilic Ornithodoros spp. act as vectors of Borrelia spp., microorganisms recognized as the agents of human Tick-borne Relapsing Fever (TBRF) in tropical and subtropical regions in the world. In South America, two species of this group were recognized in the first half of 20th century and at least one, Borrelia venezuelensis transmitted by the tick Ornithodoros rudis, was recognized as the causative agent of human TBRF outbreaks in Colômbia, Panamá, and Venezuela. Although this zoonotic disease has never been documented to occur in Brazil, another agent of the group, Borrelia brasiliensis, was once isolated from the tick Ornithodoros brasiliensis in the southern region of the country. Yet, updated reports on the occurrence of this and other agents of TBRF are currently inexistent. Notwithstanding the foregoing, the recent finding of O. rudis infected with a TBRF Borrelia in rural areas of Maranhão state, points that the occurrence of the disease might be neglected in the country. With no precedent, the current study aims to molecularly characterize in vivo- and in vitro-isolated Borrelia spp. harbored by antropophilic Ornithodoros spp. from Brazil. Additionally, serological screenings in search for Borrelia-reactive antibodies will be also performed using human blood samples collected in the prospected localities, using herein isolated spirochetes. Finally, the results of this study will refocus the attention towards a more-than-50 year-unstudied disease in South America. (AU)

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Scientific publications (18)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MUNOZ-LEAL, SEBASTIAN; VENZAL, JOSE M.; JORGE, FELIPE R.; TEIXEIRA, BRUNO M.; LABRUNA, MARCELO B. A new species of soft tick from dry tropical forests of Brazilian Caatinga. TICKS AND TICK-BORNE DISEASES, v. 12, n. 5 SEP 2021. Web of Science Citations: 0.
LABRUNA, MARCELO B.; NAVA, SANTIAGO; REBOLLO-HERNANDEZ, ANDREA; GUZMAN-CORNEJO, CARMEN; HERNANDEZ, LIGIA V.; DOMINGUEZ, LILLIAN; MUNOZ-LEAL, SEBASTIAN; VENZAL, JOSE M. Morphological descriptions of the nymph and adults of Ornithodoros clarki, the larva and nymph of Ornithodoros rondoniensis, with notes on their phylogenetic relationships. Systematic Parasitology, v. 98, n. 3 MAR 2021. Web of Science Citations: 0.
MUNOZ-LEAL, SEBASTIAN; FACCINI-MARTINEZ, ALVARO A.; PEREZ-TORRES, JAIRO; CHALA-QUINTERO, SANDRA M.; HERRERA-SEPULVEDA, MARIA T.; CUERVO, CLAUDIA; LABRUNA, MARCELO B. Novel Borrelia genotypes in bats from the Macaregua Cave, Colombia. ZOONOSES AND PUBLIC HEALTH, v. 68, n. 1, p. 12-18, FEB 2021. Web of Science Citations: 0.
PACHECO, THABATA DOS ANJOS; MUNOZ-LEAL, SEBASTIAN; MAIA, MAERLE O.; MARTINS, THIAGO F.; DE OLIVEIRA, GLAUBER M. B.; FONSECA, EDUARDO P.; PEDRONI, FERNANDO; ROSSI, ROGERIO V.; PACHECO, RICHARD C. Molecular detection of Rickettsia spp. in ticks associated with non-volant small mammals from the Brazilian Cerrado, with notes on a divergent morphotype of Ornithodoros guaporensis. INTERNATIONAL JOURNAL OF ACAROLOGY, v. 47, n. 3 FEB 2021. Web of Science Citations: 0.
MUNOZ-LEAL, SEBASTIAN; FACCINI-MARTINEZ, ALVARO A.; PEREZ-TORRES, JAIRO; CHALA-QUINTERO, SANDRA M.; HERRERA-SEPULVEDA, MARIA T.; CUERVO, CLAUDIA; LABRUNA, MARCELO B. Novel Borrelia genotypes in bats from the Macaregua Cave, Colombia. ZOONOSES AND PUBLIC HEALTH, v. 68, n. 1 NOV 2020. Web of Science Citations: 0.
MUNOZ-LEAL, SEBASTIAN; MARTINS, MARIA M.; NAVA, SANTIAGO; LANDULFO, GABRIEL A.; SIMONS, SIMONE M.; RODRIGUES, VINICIUS S.; RAMOS, VANESSA N.; SUZIN, ADRIANE; SZABO, MATIAS P. J.; LABRUNA, MARCELO B. Ornithodoros cerradoensis n. sp. (Acari: Argasidae), a member of the Ornithodoros talaje (Guerin-Meneville, 1849) group, parasite of rodents in the Brazilian Savannah. TICKS AND TICK-BORNE DISEASES, v. 11, n. 5 SEP 2020. Web of Science Citations: 0.
GARCIA-OCHAETA, JOSE FRANCISCO; JACINAVICIUS, FERNANDO DE CASTRO; BARROS-BATTESTI, DARCI MORAES; OCHOA, RONALD; BASSINI-SILVA, RICARDO. A case of co-parasitism ofSarcoptes scabiei(Linnaeus, 1758) (Sarcoptiformes: Sarcoptidae) andCheyletiella parasitivorax(Megnin, 1878) (Trombidiformes: Cheyletidae) in a European rabbit in Guatemala. INTERNATIONAL JOURNAL OF ACAROLOGY, v. 46, n. 6, p. 474-476, AUG 17 2020. Web of Science Citations: 0.
GARCIA-OCHAETA, JOSE FRANCISCO; JACINAVICIUS, FERNANDO DE CASTRO; BARROS-BATTESTI, DARCI MORAES; OCHOA, RONALD; BASSINI-SILVA, RICARDO. A case of co-parasitism ofSarcoptes scabiei(Linnaeus, 1758) (Sarcoptiformes: Sarcoptidae) andCheyletiella parasitivorax(Megnin, 1878) (Trombidiformes: Cheyletidae) in a European rabbit in Guatemala. INTERNATIONAL JOURNAL OF ACAROLOGY, v. 46, n. 6 AUG 2020. Web of Science Citations: 0.
MUNOZ-LEAL, SEBASTIAN; DOMINGUEZ, LILLIAN; ARMSTRONG, BRITTANY A.; LABRUNA, MARCELO B.; BERMUDEZ, SERGIO C. Ornithodoros capensissensu stricto (Ixodida: Argasidae) in Coiba National Park: first report for Panama, with notes on theO. capensisgroup in Panamanian shores and Costa Rica. Experimental and Applied Acarology, v. 81, n. 3, p. 469-481, JUL 2020. Web of Science Citations: 0.
MUNOZ-LEAL, SEBASTIAN; RAMIREZ, DIEGO G.; LUZ, HERMES R.; FACCINI, JOAO L. H.; LABRUNA, MARCELO B. ``Candidatus Borrelia ibitipoquensis,{''} a Borrelia valaisiana-Related Genospecies Characterized from Ixodes paranaensis in Brazil. MICROBIAL ECOLOGY, v. 80, n. 3 MAY 2020. Web of Science Citations: 3.
SEVA, ANAIA DA PAIXAO; MARTINS, THIAGO FERNANDES; MUNOZ-LEAL, SEBASTIAN; RODRIGUES, ANA CARLA; PINTER, ADRIANO; LUZ, HERMES R.; ANGERAMI, RODRIGO N.; LABRUNA, MARCELO B. A human case of spotted fever caused by Rickettsia parkeri strain Atlantic rainforest and its association to the tick Amblyomma ovale. PARASITES & VECTORS, v. 12, n. 1 OCT 11 2019. Web of Science Citations: 0.
BASSINI-SILVA, RICARDO; JACINAVICIUS, FERNANDO DE CASTRO; MUNOZ-LEAL, SEBASTIAN; TERASSINI, FLAVIO A.; BARBOZA DE OLIVEIRA, GLAUBER MENESES; WELBOURN, CAL; SUNDIC, MILOJE; LABRUNA, MARCELO BAHIA; BARROS-BATTESTI, DARCI MORAES. Leptus (Leptus) simonettae Haitlinger, 2000 (Trombidiformes: Erythraeidae) parasitizing a soft tick (Ixodida: Argasidae) in Brazil. INTERNATIONAL JOURNAL OF ACAROLOGY, v. 45, n. 6-7, p. 409-412, OCT 3 2019. Web of Science Citations: 0.
DANTAS-TORRES, FILIPE; MARTINS, THIAGO FERNANDES; MURIOZ-LEAL, SEBASTIAN; ONOFRIO, VALERIA CASTILHO; BARROS-BATTESTI, DARCI MORAES. Ticks (Ixodida: Argasidae, Ixodidae) of Brazil: Updated species checklist and taxonomic keys. TICKS AND TICK-BORNE DISEASES, v. 10, n. 6 OCT 2019. Web of Science Citations: 1.
MUNOZ-LEAL, SEBASTIAN; TERASSINI, FLAVIO A.; MARCILI, ARLEI; OLIVEIRA, GLAUBER M. B.; CAMARGO, LUIS MARCELO A.; LABRUNA, MARCELO B. A third species of Nothoaspis Keirans & Clifford, 1975 (Acari: Argasidae): Nothoaspis setosus (Kohls, Clifford & Jones, 1969) n. comb. Systematic Parasitology, v. 96, n. 7, p. 595-602, SEP 2019. Web of Science Citations: 0.
MUNOZ-LEAL, SEBASTIAN; MARCILI, ARLEI; FUENTES-CASTILLO, DANNY; AYALA, MAURICIO; LABRUNA, MARCELO B. A relapsing fever Borrelia and spotted fever Rickettsia in ticks from an Andean valley, central Chile. Experimental and Applied Acarology, v. 78, n. 3, p. 403-420, JUL 2019. Web of Science Citations: 0.
MUNOZ-LEAL, SEBASTIAN; MACEDO, CATARINA; GONCALVES, TERESA CRISTINA; BARREIRA, JAIRO DIAS; LABRUNA, MARCELO B.; SAMPAIO DE LEMOS, ELBA REGINA; OGRZEWALSKA, MARIA. Detected microorganisms and new geographic records of Ornithodoros rietcorreai (Acari: Argasidae) from northern Brazil. TICKS AND TICK-BORNE DISEASES, v. 10, n. 4, p. 853-861, JUN 2019. Web of Science Citations: 2.
MUNOZ-LEAL, S.; BARBIER, E.; SOARES, F. A. M.; BERNARD, E.; LABRUNA, M. B.; DANTAS-TORRES, F. New records of ticks infesting bats in Brazil, with observations on the first nymphal stage of Ornithodoros hasei. Experimental and Applied Acarology, v. 76, n. 4, p. 537-549, DEC 2018. Web of Science Citations: 2.
MUNOZ-LEAL, SEBASTIAN; TERASSINI, FLAVIO A.; LUZ, HERMES R.; FONTANA, ISABELLA; CAMARGO, LUIS MARCELO A.; LABRUNA, MARCELO B. First report of Ornithodoros peropteryx in Brazil, and the occurrence of Ornithodoros cavernicolous in the western Brazilian Amazon. SYSTEMATIC AND APPLIED ACAROLOGY, v. 23, n. 11, p. 2113-2121, NOV 2018. Web of Science Citations: 4.

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