Identification of co-expression genes in Nellore cattle muscle tissue with divergent marbling and myofibrilar fragmentation index phenotypes, using RNA-Seq data

• Grant number: 18/11154-2
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: September 03, 2018
• End date: August 30, 2019
• Field of knowledge: Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
• Principal Investigator: Lucia Galvão de Albuquerque
• Grantee: Maria Malane Magalhães Muniz
• Supervisor: Angela Canovas
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
• Institution abroad: University of Guelph, Canada
• Associated to the scholarship: 17/04270-3 - STUDY OF TRANSCRIPTOMA OF MUSCULAR TISSUE OF NELORE BREED BOVINE DIVERGENS FOR MEAT QUALITY, BP.DR

Abstract

Meat quality traits are difficult to measure and not often included in current breedingprograms. However, due to the great economic importance of these traits, research toimprove our knowledge on the molecular factors and mechanisms that control theexpression of these traits is increasing. This project aims to evaluate the differential coexpressionof genes in Nellore bulls muscle tissue, within extreme groups formyofibrillar fragmentation index (MFI) and marbling phenotypes, using data fromtranscripts obtained by RNA-Seq. From this information, associations between theexpression of isoforms and the differential co-expression gene between the divergentgroups can be performed, which will produce a better understanding of the molecularmechanisms involved with marbling and tenderness related traits.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MAGALHAES MUNIZ, MARIA MALANE; SIMIELLI FONSECA, LARISSA FERNANDA; DOS SANTOS SILVA, DANIELLY BERALDO; DE OLIVEIRA, HINAYAH ROJAS; BALDI, FERNANDO; CHARDULO, ARTUR LOYOLA; FERRO, JESUS APARECIDO; CANOVAS, ANGELA; DE ALBUQUERQUE, LUCIA GALVAO. Identification of novel mRNA isoforms associated with meat tenderness using RNA sequencing data in beef cattle. MEAT SCIENCE, v. 173, MAR 2021. (18/20026-8, 11/21241-0, 18/11154-2, 09/16118-5, 17/10630-2)

MAGALHAES MUNIZ, MARIA MALANE; SIMIELLI FONSECA, LARISSA FERNANDA; BECKER SCALEZ, DAIANE CRISTINA; VEGA, AROA SUAREZ; DOS SANTOS SILVA, DANIELLY BERALDO; FERRO, JESUS APARECIDO; CHARDULO, ARTUR LOYOLA; BALDI, FERNANDO; CANOVAS, ANGELA; DE ALBUQUERQUE, LUCIA GALVAO. Characterization of novel lncRNA muscle expression profiles associated with meat quality in beef cattle. EVOLUTIONARY APPLICATIONS, v. 15, n. 4, p. 13-pg., 2022-03-25. (18/11154-2, 18/20026-8, 09/16118-5, 17/10630-2, 11/21241-0)

MUNIZ, MALANE M.; SIMIELLI FONSECA, LARISSA FERNANDA; CANOVAS, ANGELA; DOS SANTOS SILVA, DANIELLY BERALDO; FERRO, JESUS APARECIDO; CHARDULO, ARTUR LOYOLA; BALDI, FERNANDO; DE ALBUQUERQUE, LUCIA GALVAO. Structural variants affecting mRNAs isoforms splice sites associated with marbling in Nellore cattle. JOURNAL OF ANIMAL SCIENCE, v. 98, p. 2-pg., 2020-11-01. (18/11154-2, 11/21241-0, 09/16118-5, 18/20026-8, 17/10630-2)

MAGALHAES MUNIZ, MARIA MALANE; SIMIELLI FONSECA, LARISSA FERNANDA; DOS SANTOS SILVA, DANIELLY BERALDO; BRAGA MAGALHAES, ANA FABRICIA; FERRO, JESUS APARECIDO; LOYOLA CHARDULO, LUIZ ARTUR; BALDI, FERNANDO; CANOVAS, ANGELA; DE ALBUQUERQUE, LUCIA GALVAO. Small genetic variation affecting mRNA isoforms associated with marbling and meat color in beef cattle. FUNCTIONAL & INTEGRATIVE GENOMICS, v. N/A, p. 16-pg., 2022-03-19. (09/16118-5, 17/10630-2, 18/11154-2, 11/21241-0, 18/20026-8)