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Effects of anchor-abdominoplasty in metabolic profile of patients submitted to post-bariatric plastic surgery

Grant number: 17/19887-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2018
Effective date (End): July 31, 2019
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Pedro Soler Coltro
Grantee:Beatriz Edla Caetano
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Patients submitted to bariatric surgery have body contour deformities, mainly in the abdominal region, due to massive weight loss. In this sense, the performance of abdominoplasties has increased. In addition to improving the aesthetic, psychosocial aspects and prevention of complications due to excess skin and fat, it is believed that the removal of cutaneous-greasy tissue, promoted by post-bariatric anchor-abdominoplasty by improving the fat distribution pattern, would contribute to reduce the risk of metabolic disorders and cardiovascular diseases. However, currently studies of these effects are still inconclusive because they do not agree among themselves. Associated to this, there are no studies evaluating specifically the effects of post-bariatric anchor-abdominoplasty in the metabolism. The objective of this prospective study is therefore to evaluate the effects of this surgical intervention on the metabolic profile of patients after bariatric surgery. In this way, it will be seen if it correlates with better metabolic indicators in this group, which may corroborate with the maintenance of the expected effect with reductive gastroplasty. Patients and methods: initially, 15 patients will be included, who will undergo abdominal dermolipectomy at HCFMRP-USP. The following parameters will be analyzed pre and post-operative in order to study the quantity, distribution and functionality of remaining adipose tissue: body composition, skin folds, waist-hip ratio, waist circumference, blood pressure, lipidogram, uricemia, glycemia, fasting insulinemia, insulin sensitivity (HOMA-IR), adipokines in serum and estimation of insulin resistance from oral glucose overload test (TTOG), only the latter test being performed before and 180 days later of the surgery and all others measured before and at 30, 90 and 180 days after surgery. Statistical analysis of the data will be performed using parametric (Student t test) and non-parametric tests. The comparison of parameters over the study will be performed using the Wilcoxon test or paired t-test. The level of significance adopted will be p <0.05.