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Effects of treatment with ocitocin in the process of bone remodeling of the column of rats fist in periestropausa

Grant number: 18/07023-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2018
Effective date (End): December 31, 2018
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Rita Cássia Menegati Dornelles
Grantee:Tainá Santos Pestana
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

The incidence of osteoporosis (OP), according to the literature, is higher in females in the menopausal period, related to deficiency of the gonadal steroid, a fundamental hormone in the activity of bone remodeling, which contributes to bone growth and peak bone mass. Among the new therapies, oxytocin (OT) has been investigated for its anabolic effects on bone tissue. Objective: The objective of this study is to analyze the action of OT in the process of bone remodeling of the femoral neck of rats with irregular estrous cycle in the period of peri-mastopeuse and to verify possible action in the prevention of PO. Material and method: 20 Wistar rats with initial age of 18 months will be used in the following groups: 1 - Control (C) and 2 - Oxytocin (OT) with 10 animals each. During 120 days the animals of the OT group will receive 2 intraperitoneal OT injections at a dose of 134¼g / kg with a 12 hour interval every 30 days, totaling 8 injections. After the treatment period, analyzes of bone remodeling markers in the serum and analysis of densitometry, bone microtomography, mechanical assay and dosage of calcium and phosphorus in the femur of these animals will be performed to verify the effects of OT.

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