The aging in the female organism is marked by the smallest estrogen plasmatic concentration, risk factor thoroughly recognized for osteoporosis. Another factor that is involved in the hormonal alterations happened in the menopause and in the physiopathology of the primary osteoporosis is the oxidative stress. Therapeutic proposal that contributes to improvement of the oxidative profile and bone quality is the strength training (ST). Objective: Analyze the performance of ST in the bone quality in the femoral neck area of female rats in the periestropausa period and the possible correlation with markers of the oxidative stress, reducing the osteopenia risks and primary osteoporosis. Material and method: It will use 20 female Wistar rats with initial age of 18 months old that will be distributed in the following groups: 1 - Control (C) and 2 - Strength Training (ST) with 10 animals per group. During 120 days ST animals will perform strength training three times per week. After ST period it will do analysis of bone remodeling serum markes, oxidative stress plasm markers and bone densitometry, bone microtomography, mechanical test and femoral calcium and phosphorus these animals to verify ST effects.
News published in Agência FAPESP Newsletter about the scholarship: