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Analysis of the femoral neck in periestropaused rats submitted to different physical training methods

Grant number: 19/21335-7
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2020
Effective date (End): June 30, 2020
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal Investigator:Rita Cássia Menegati Dornelles
Grantee:Otavio Henrique Breyer
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Aging is caused by cellular and molecular damage that results in progressive disability of some functions. Bone tissue, especially in postmenopausal women, can be greatly affected by osteopenia and the installation of osteoporosis. Studies have shown the effectiveness of aerobic exercise, strength and Concurrent Training in maintaining bone health and preventing bone loss. Objective: The aim of this study will be to evaluate the effect of different physical training methods on bone quality of Wistar rats during the periestropause period. Method: This study will be performed with 40 female Wistar rats with an initial age of 17 months and an irregular estrous cycle, kept in a temperature-controlled environment (22 ± 2 ° C), humidity (55 ± 10%), light cycle inverted (12/12h), and free access to water and feed (CEUA: 826-2018). The animals will constitute the groups: 1- Control, adherence to physical exercise and not submitted to training (NT); 2- Aerobic Training (AT); 3- Resistance Training (RT); 4- Concurrent Training (CT). The training will be conducted according to defined protocols: three times a week for four months. After the training period, collect will be performed to remove the right femurs for bone densitometry analysis (DEXA), bone microtomography (µCT) and mechanical test. Blood will be collected for analysis of bone metabolism markers: tartrate-resistant acid phosphatase (TRAP) and alkaline phosphatase activity (ALP). Expected Outcomes: Our hypothesis is that physical exercise during the specific period of periestropause will improve bone quality and Concurrent Training will contribute most effectively to the prevention of primary osteoporosis and anti-fracture effect during aging.

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