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Individual muscle protein synthesis responses to the modulation of resistance training variables

Grant number: 18/13064-0
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): September 15, 2018
Effective date (End): January 14, 2019
Field of knowledge:Health Sciences - Physical Education
Principal researcher:Cleiton Augusto Libardi
Grantee:Felipe Romano Damas Nogueira
Supervisor abroad: Oliver C. Witard
Home Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Research place: University of Stirling, Scotland  
Associated to the scholarship:16/24259-1 - Human biological individuality versus resistance-training variables modulation: what really matters for muscle hypertrophy?, BP.PD


The individual hypertrophic responses to resistance training (RT) is highly variable and could be one of the main reasons why some RT protocols do not result in positive muscle adaptations in all individuals. Our group successfully investigated (FAPESP funded, #2012/24499-1, #2014/19594-0 and #2013/21218-4) the relation between acute integrated myofibrillar protein synthesis (MyoPS) and chronic hypertrophy in different RT phases. In this project we aim to determine the individual MyoPS responses to RT protocols manipulating variables (e.g., load, number of sets, type of contraction, rest between sets) vs. a control RT protocol, when all are performed up to muscle fatigue. Using an unilateral design in trained men we want to evaluate a currently unanswered question: is there any importance of manipulating RT variables when applying RT up to muscle fatigue, or is fatigue really enough to maximize MyoPS independent of other RT modulations? We propose to analyse the MyoPS responses in 20 previously trained men following an acute RT session in which one leg performed a control RT protocol (RT-CON) - leg 1 (n=20) and the contralateral leg performed RT with either load variation, sets, contraction type or rest interval (RT-VAR) - leg 2 (n=5 per condition). For MyoPS measurements, subjects ingested deuterated water two days before the acute protocols, saliva samples were collected daily and bilateral muscle biopsies were conducted before and 24h and 48h after the protocols. Our hypothesis is that the inter-individuals variability of the MyoPS response will be high, and performing distinct RT protocols can promote slight differences in intra-individual MyoPS response. However, since all RT protocols proposed herein are all are performed to fatigue resulting in moderate to high training volumes, maybe the slight changes in MyoPS will not be enough to show significant differences in the intra-individual MyoPS response among RT protocols.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DAMAS, FELIPE; ANGLERI, VITOR; PHILLIPS, STUART M.; WITARD, OLIVER C.; UGRINOWITSCH, CARLOS; SANTANIELO, NATALIA; SOLIGON, SAMUEL D.; COSTA, LUIZ A. R.; LIXANDRAO, MANOEL E.; CONCEICAO, MIGUEL S.; et al. Myofibrillar protein synthesis and muscle hypertrophy individualized responses to systematically changing resistance training variables in trained young men. Journal of Applied Physiology, v. 127, n. 3, p. 806-815, . (18/13064-0, 16/24259-1, 17/04299-1, 17/05331-6)
DAMAS, FELIPE; UGRINOWITSCH, CARLOS; LIBARDI, CLEITON A.; JANNIG, PAULO R.; HECTOR, AMY J.; MCGLORY, CHRIS; LIXANDRAO, MANOEL E.; VECHIN, FELIPE C.; MONTENEGRO, HORACIO; TRICOLI, VALMOR; et al. Resistance training in young men induces muscle transcriptome-wide changes associated with muscle structure and metabolism refining the response to exercise-induced stress. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 118, n. 12, p. 2607-2616, . (13/21218-4, 12/24499-1, 14/19594-0, 18/13064-0, 17/04299-1, 16/24259-1)
ALVAREZ, IEDA FERNANDA; DAMAS, FELIPE; PIRES DE BIAZON, THAIS MARINA; MIQUELINI, MAIARA; DOMA, KENJI; LIBARDI, CLEITON AUGUSTO. Muscle damage responses to resistance exercise performed with high-load versus low-load associated with partial blood flow restriction in young women. European Journal of Sport Science, v. 20, n. 1, . (16/24259-1, 13/21218-4, 18/13064-0)

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