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Effects of resistance exercise volume on the variability of the hypertrophic response in ELDELY

Grant number: 16/22635-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2017
Effective date (End): April 30, 2020
Field of knowledge:Health Sciences - Physical Education
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal researcher:Hamilton Augusto Roschel da Silva
Grantee:Manoel Emílio Lixandrão
Home Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):18/15691-2 - EFFECTS OF RESISTANCE EXERCISE VOLUME ON THE VARIABILITY OF THE HYPERTROPHIC RESPONSE IN ELDERLY, BE.EP.DR

Abstract

Aging is associated with a progressive loss of skeletal muscle mass, which ultimately reduces the functional capacity. Accordingly, moderate- to high-load resistance exercise (RE) (i.e., > 65% of one repetition maximum) has been well established as an effective strategy to promote muscle mass accrual in elderly. However, there is substantial inter-individual variability in resistance exercise-mediated changes in muscle mass, with some elderly at the lower end of the spectrum showing only small or even insignificant increases in muscle mass (i.e., low-responders). Nevertheless, it has been suggested that low-responsiveness may be related to a lower sensibility to the anabolic effect of RE (i.e., lower increases in protein synthesis) rather than to a reduced capacity to increase muscle mass content. Thus, it seems possible that even low-responders may benefit from RE if proper modulations in exercise variables are provided. In this regard, RE volume has been demonstrated to be associated with increased muscle mass accrual after RE in a variety of populations. Therefore, it seems appealing to hypothesize that RE volume manipulation may constitute a potentially effective strategy to minimize low-responsiveness in elderly individuals. Furthermore, low-responsiveness also seems to be related with suboptimal activation of the myogenic program, responsible to regulate satellite cells and myonuclei content. Provided that satellite cells and myonuclei content seem to be crucial for RE-mediated changes in muscle mass, it is important to understand the effects of RE volume on these parameters in low-responders. Therefore, the present study aims to investigate the effects of different RE volumes on muscle mass in low-responders elderly. A secondary purpose is to investigate these effects on satellite cells and myonuclei responses in these individuals. For such, the experimental design will be composed of 10 weeks of RE with a frequency of two sessions per week. Each leg of a specific subject will be randomly allocated, considering dominance, in one of the two possible conditions: 1) one set of 8-10 maximum repetitions and; 2) four sets of 8-10 maximum repetitions. Before training period, all subjects will be submitted to an ultrasonography exam, one repetition maximum test and one muscle biopsy in the vastus lateralis muscle (the right or left leg will be selected randomly). These same procedures will be performed after the intervention period, however, at this moment two muscle biopsies will be performed, one biopsy in each leg of a specific subject. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LIXANDRAO, MANOEL E.; LONGOBARDI, IGOR; LEITAO, ALICE E.; MORAIS, JOAO V. M.; SWINTON, PAUL A.; AIHARA, ANDRE Y.; GOES, PAOLA C. K.; UGRINOWITSCH, CARLOS; CANDOW, DARREN G.; GUALANO, BRUNO; et al. Daily Leucine Intake Is Positively Associated with Lower Limb Skeletal Muscle Mass and Strength in the Elderly. NUTRIENTS, v. 13, n. 10, . (16/22635-6)
DAMAS, FELIPE; BARCELOS, CINTIA; NOBREGA, SANMY R.; UGRINOWITSCH, CARLOS; LIXANDRAO, MANOEL E.; SANTOS, LUCAS M. E. D.; CONCEICAO, MIGUEL S.; VECHIN, FELIPE C.; LIBARDI, CLEITON A.. INDIVIDUAL MUSCLE HYPERTROPHY AND STRENGTH RESPONSES TO HIGH VS. LOW RESISTANCE TRAINING FREQUENCIES. JOURNAL OF STRENGTH AND CONDITIONING RESEARCH, v. 33, n. 4, p. 897-901, . (16/24259-1, 17/04299-1, 13/21218-4, 16/22635-6)
LIXANDRAO, MANOEL E.; UGRINOWITSCH, CARLOS; BERTON, RICARDO; VECHIN, FELIPE C.; CONCEICAO, MIGUEL S.; DAMAS, FELIPE; LIBARDI, CLEITON A.; ROSCHEL, HAMILTON. Magnitude of Muscle Strength and Mass Adaptations Between High-Load Resistance Training Versus Low-Load Resistance Training Associated with Blood-Flow Restriction: A Systematic Review and Meta-Analysis. SPORTS MEDICINE, v. 48, n. 2, p. 361-378, . (16/10993-5, 16/09759-8, 16/22635-6)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LIXANDRÃO, Manoel Emílio. Effects of resistance exercise volume on the variability of the hypertrophic response in eldery. 2020. Doctoral Thesis - Universidade de São Paulo (USP). Escola de Educação Física e Esportes (EEFE/BT) São Paulo.

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