Development, evaluation of the anti-inflammatory potential, safety and quality, of a new herbal enriched with agave sisalana extract encapsulated in liposomes

• Grant number: 17/26783-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2018
• End date: June 30, 2019
• Field of knowledge: Biological Sciences - Pharmacology - Ethnopharmacology
• Principal Investigator: Lucinéia dos Santos
• Grantee: Letícia Yurie Kuae
• Host Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil

Abstract

The use of plant extracts is a growing trend in the drug industry. In accordance with this trend, it was possible to verify that the improved extract of Agave sisalana, a plant popularly known as sisal, presented potent analgesic and anti-inflammatory activities, which is probably due to the presence of saponins found in the test phytochemical. However, the inclusion of the extract into a cream formulation promoted some changes in the organoleptic properties of the product, mainly in its color and odor. Thus, this work proposes the inclusion of a new technology, nanotechnology, which will allow the improvement of the formulation and probably prevent the occurrence of quality defects presented. To ensure that the technology employed will not interfere with the efficacy and safety of the product to be developed, the toxicological and anti-inflammatory potentials of the encapsulated sisal extract in vitro, as well as the anti-inflammatory potential of the cream in vivo, will be evaluated. Finally, new quality control tests of the cream enriched with the encapsulated sisal extract will be performed.