Depression is a debilitating disorder and the biggest cause of suicide in the world. It is a complex and multifactorial disease, as well as being a common comorbidity in serious pathologies, including Alzheimer's disease. The peculiarities of depression in adults over 55 years form a heterogeneous syndrome called Late-life Depression (LLD), which affects about 6.5% of the world's elderly. The search for indicative biomarkers of early onset of depression is imperative, as well as to understand molecular mechanisms that link aging to physiology of late-life depression, due to population growth and aging. Potential biomarkers will be identified from human blood plasma of 25 elderly diagnosed with late-life depression, antidepressants-free, through proteomic research using mass spectrometry. Furthermore, late-life depression biochemical pathways can be identified using in silico systems biology analysis tools. These data will help to delineate the molecular basis of late-life depression, allowing an integrated view of disease multiple biological processes, contributing to the paradigm shift of late-life depression in elderly.
News published in Agência FAPESP Newsletter about the scholarship: