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Identification of blood-based biomarkers for late-life depression through proteomics

Grant number: 18/03422-7
Support type:Scholarships in Brazil - Master
Effective date (Start): September 01, 2018
Effective date (End): December 31, 2019
Field of knowledge:Biological Sciences - Biochemistry
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Daniel Martins-de-Souza
Grantee:Licia Carla da Silva Costa
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/08711-3 - Developing a predictive test for a successful medication response and understanding the molecular bases of schizophrenia through proteomics, AP.JP

Abstract

Depression is a debilitating disorder and the biggest cause of suicide in the world. It is a complex and multifactorial disease, as well as being a common comorbidity in serious pathologies, including Alzheimer's disease. The peculiarities of depression in adults over 55 years form a heterogeneous syndrome called Late-life Depression (LLD), which affects about 6.5% of the world's elderly. The search for indicative biomarkers of early onset of depression is imperative, as well as to understand molecular mechanisms that link aging to physiology of late-life depression, due to population growth and aging. Potential biomarkers will be identified from human blood plasma of 25 elderly diagnosed with late-life depression, antidepressants-free, through proteomic research using mass spectrometry. Furthermore, late-life depression biochemical pathways can be identified using in silico systems biology analysis tools. These data will help to delineate the molecular basis of late-life depression, allowing an integrated view of disease multiple biological processes, contributing to the paradigm shift of late-life depression in elderly.