Identification of blood-based biomarkers for late-life depression through proteomics

• Grant number: 18/03422-7
• Support Opportunities: Scholarships in Brazil - Master
• Start date: September 01, 2018
• End date: December 31, 2019
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Daniel Martins-de-Souza
• Grantee: Licia Carla da Silva Costa
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/08711-3 - Developing a predictive test for a successful medication response and understanding the molecular bases of schizophrenia through proteomics, AP.JP

Abstract

Depression is a debilitating disorder and the biggest cause of suicide in the world. It is a complex and multifactorial disease, as well as being a common comorbidity in serious pathologies, including Alzheimer's disease. The peculiarities of depression in adults over 55 years form a heterogeneous syndrome called Late-life Depression (LLD), which affects about 6.5% of the world's elderly. The search for indicative biomarkers of early onset of depression is imperative, as well as to understand molecular mechanisms that link aging to physiology of late-life depression, due to population growth and aging. Potential biomarkers will be identified from human blood plasma of 25 elderly diagnosed with late-life depression, antidepressants-free, through proteomic research using mass spectrometry. Furthermore, late-life depression biochemical pathways can be identified using in silico systems biology analysis tools. These data will help to delineate the molecular basis of late-life depression, allowing an integrated view of disease multiple biological processes, contributing to the paradigm shift of late-life depression in elderly.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA-COSTA, LICIA C.; GARCIA-ROSA, SHEILA; SMITH, BRADLEY J.; BALDASSO, PAULO A.; STEINER, JOHANN; MARTINS-DE-SOUZA, DANIEL. Blood plasma high abundant protein depletion unintentionally carries over 100 proteins. SEPARATION SCIENCE PLUS, OCT 2019. (13/08711-3, 17/25588-1, 16/07948-8, 18/03422-7, 14/10068-4, 19/05747-3)

SILVA-COSTA, LICIA C.; SMITH, BRADLEY J.; CARREGARI, VICTOR CORASOLLA; SOUZA, GUSTAVO H. M. F.; VIEIRA, ERICA M.; MENDES-SILVA, ANA PAULA; ALMEIDA, VALERIA DE; CARVALHO, BENILTON S.; DINIZ, BRENO S.; MARTINS-DE-SOUZA, DANIEL. Plasma proteomic signature of major depressive episode in the elderly. JOURNAL OF PROTEOMICS, v. 269, p. 9-pg., 2022-10-30. (14/10068-4, 19/05155-9, 17/18242-1, 20/09165-6, 16/07948-8, 19/05747-3, 17/25588-1, 19/00098-7, 18/03422-7)

SILVA-COSTA, LICIA C.; GARCIA-ROSA, SHEILA; SMITH, BRADLEY J.; BALDASSO, PAULO A.; STEINER, JOHANN; MARTINS-DE-SOUZA, DANIEL. Blood plasma high abundant protein depletion unintentionally carries over 100 proteins. SEPARATION SCIENCE PLUS, v. 2, n. 12, p. 8-pg., 2019-10-21. (16/07948-8, 19/05747-3, 17/25588-1, 13/08711-3, 18/03422-7, 14/10068-4)

FALVELLA, ANA CAROLINE BRAMBILLA; SMITH, BRADLEY JOSEPH; SILVA-COSTA, LICIA C.; VALENCA, ALINE G. F.; CRUNFLI, FERNANDA; ZUARDI, ANTONIO W.; HALLAK, JAIME E.; CRIPPA, JOSE A.; ALMEIDA, VALERIA DE; MARTINS-DE-SOUZA, DANIEL. Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. FRONTIERS IN MOLECULAR NEUROSCIENCE, v. 14, MAY 28 2021. (18/03422-7, 08/09009-2, 17/18242-1, 19/00098-7, 17/25588-1, 19/22398-2, 18/10362-0, 18/03450-0, 18/03673-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

COSTA, Licia Carla da Silva. Understanding late-life depression employing system biology-based proteomics. 2020. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.