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Identification of blood-based biomarkers for late-life depression through proteomics

Grant number: 18/03422-7
Support type:Scholarships in Brazil - Master
Effective date (Start): September 01, 2018
Effective date (End): December 31, 2019
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Daniel Martins-de-Souza
Grantee:Licia Carla da Silva Costa
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/08711-3 - Developing a predictive test for a successful medication response and understanding the molecular bases of schizophrenia through proteomics, AP.JP

Abstract

Depression is a debilitating disorder and the biggest cause of suicide in the world. It is a complex and multifactorial disease, as well as being a common comorbidity in serious pathologies, including Alzheimer's disease. The peculiarities of depression in adults over 55 years form a heterogeneous syndrome called Late-life Depression (LLD), which affects about 6.5% of the world's elderly. The search for indicative biomarkers of early onset of depression is imperative, as well as to understand molecular mechanisms that link aging to physiology of late-life depression, due to population growth and aging. Potential biomarkers will be identified from human blood plasma of 25 elderly diagnosed with late-life depression, antidepressants-free, through proteomic research using mass spectrometry. Furthermore, late-life depression biochemical pathways can be identified using in silico systems biology analysis tools. These data will help to delineate the molecular basis of late-life depression, allowing an integrated view of disease multiple biological processes, contributing to the paradigm shift of late-life depression in elderly.

News published in Agência FAPESP Newsletter about the scholarship:
A method that facilitates the discovery of biomarkers for psychiatric and immune-related diseases 

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA-COSTA, LICIA C.; GARCIA-ROSA, SHEILA; SMITH, BRADLEY J.; BALDASSO, PAULO A.; STEINER, JOHANN; MARTINS-DE-SOUZA, DANIEL. Blood plasma high abundant protein depletion unintentionally carries over 100 proteins. SEPARATION SCIENCE PLUS, OCT 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.