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The role of natural selection on the diversification of Native American populations

Grant number: 17/14916-8
Support Opportunities:Scholarships in Brazil - Doctorate
Start date: December 01, 2018
End date: August 31, 2020
Field of knowledge:Biological Sciences - Genetics - Human and Medical Genetics
Principal Investigator:Tábita Hünemeier
Grantee:Cainã Max Couto da Silva
Host Institution: Instituto de Biociências (IB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:15/26875-9 - Native American genome diversity, AP.JP

Abstract

First humans arrived in America about 15,000 years ago through Bering Strait, a land bridge connecting the northwest American continent to the northeast Asian continent during the Last Glacial Maximum (LGM). After entering America, first Americans quickly spread themselves across the continent, inhabiting all altitudes in less than 5,000 years. During such expansion, these first migrants faced up extreme ecosystems, such as Andes highlands and the Amazon rainforest. In addition, over time, different modes of subsistence were developed: in the Andes and Mesoamerica, hunter-gathers gave rise to great agriculturalist societies, while in the Amazonian and Sub-Amazonian regions, populations have improved the hunter-gatherer lifestyle over the time. Although America is an excellent model for studying the role of natural selection in the population diversification, since it presents populations adapted to different ecosystem and mode of subsistence, there are few studies regarding this subject. Therefore, this present project aims to study Native American populations from different ecoregions (Andes, Amazonia, and Mesoamerica), looking for possible molecular marks left by adaptive processes to which such populations were exposed throughout their evolutionary history. For this purpose, we will use genomic data (SNP arrays) of 22 Native American populations (328) individuals) from Mesoamerica, Andes, and Amazonia, previously published in the literature, as well as data that will be generated for this project. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CASTRO E SILVA, MARCOS ARAUJO; FERRAZ, TIAGO; COUTO-SILVA, CAINA M.; LEMES, RENAN B.; NUNES, KELLY; COMAS, DAVID; HUNEMEIER, TABITA. Population Histories and Genomic Diversity of South American Natives. Molecular Biology and Evolution, v. 39, n. 1, p. 17-pg., . (15/26875-9, 20/10136-0, 17/14916-8, 16/12371-1)
COUTO-SILVA, CAINA M.; NUNES, KELLY; VENTURINI, GABRIELA; CASTRO E SILVA, MARCOS ARAUJO; PEREIRA, LYGIA, V; COMAS, DAVID; PEREIRA, ALEXANDRE; HUNEMEIER, TABITA. Indigenous people from Amazon show genetic signatures of pathogen-driven selection. SCIENCE ADVANCES, v. 9, n. 10, p. 1-pg., . (15/26875-9, 17/14916-8, 19/11821-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Cainã Max Couto da. Influence of natural selection on native populations from distinct American ecoregions. 2021. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Biociências (IBIOC/SB) São Paulo.