Endrigue TC. Determinants of aerobic capacity in subjects with asthma undergoing a physical exercise program. São Paulo: "Faculdade de Medicina, Universidade de São Paulo"; 2018. Introduction: Asthma is defined as "a heterogeneous disease, usually characterized by chronic inflammation of the airways" (GINA, 2018). The symptoms resulting from the disease contribute to the limitation of the physical activity associated to the decrease of the activities of daily life and to the increase of the levels of anxiety and depression, culminating in the compromise of the quality of life. Moderate physical exercise in patients with asthma promotes the modulation of anti-inflammatory and immune responses, producing several benefits, such as increasing maximal aerobic capacity, reducing symptoms of the disease and improving quality of life. Up to date, no study has specifically defined the determinants related to physical capacity limitation in patients with asthma, nor the improvements resulting from aerobic physical training. Objective: To evaluate the ventilator, cardiovascular and metabolic responses related to the limitation of exercise and to the increase of the physical capacity due to the physical training in individuals with asthma. Also, clinical control and factors related to the quality of life will be evaluated. Methods: This is a retrospective study in which cardiopulmonary exercise tests of 129 patients with moderate to severe asthma who underwent aerobic physical training in previous studies will be analyzed. Data for ventilator, cardiovascular and metabolic variables will be assessed before and after the intervention period. The clinical control data will be analyzed from the score observed in the Asthma Control Questionnaire (ACQ) and health factors related to quality of life will be evaluated through the Asthma Quality of Life Questionnaire (AQLQ).
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