Glomerular mesangial cells mitochondrial dynamics alterations in hyperglycemia followed by mesenchymal stem cell therapy

• Grant number: 17/18072-9
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2019
• End date: January 31, 2020
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Érika Bevilaqua Rangel
• Grantee: Christian Sávio Silva
• Host Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil

Abstract

Diabetes is an epidemic disease with increasing incidence over the world, causing multiple complications. Diabetic Nephropathy is one of the main disturbs caused by diabetic hyperglycemia, which is characterized by progressive loss of glomerular filtration rate and affects over 40% of diabetic patients. Oxidative stress, which is one of the main players in Diabetic Nephropathy pathogenesis development, affects especially, in a way that disturbs oxidative phosphorylation and culminates in even more ROS production. Increasing body of evidences demonstrates mitochondria impairment as a causal link of the main Diabetes damage pathways and also that interventions to equilibrate mitochondria dynamics can prevent alterations caused by hyperglycemia. Mitochondria have a special - however limited - ability to deal with insults, which is called Quality Control Program (biogenesis, mitophagy, fusion, fission). Cell therapy is a promising treatment tool for diabetic nephropathy, and recently it has been demonstrated that besides the well described paracrine effects, mesenchymal stem cells have the ability to directly transfer their own mitochondria to damaged cells. Our research aims to apply stem cell therapy in a diabetic nephropathy in vitro model and also to assess the influence of direct mitochondria transfer in regeneration efficacy. Finally, one of the questions to be elucidated is: what is the importance to have stem cells present and directly making contact with the injured cells? (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SAVIO-SILVA, CHRISTIAN; BEYERSTEDT, STEPHANY; SOINSKI-SOUSA, POLIANA E.; CASARO, EXPEDITO B.; BALBY-ROCHA, MARIA THERESA A.; SIMPLICIO-FILHO, ANTONIO; ALVES-SILVA, JAMILLE; RANGEL, ERIKA B.. Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells. STEM CELLS INTERNATIONAL, v. 2020, NOV 20 2020. (17/18072-9, 19/12636-3, 18/24562-1)

RANGEL, ERIKA B.; RODRIGUES, CLAUDIA O.; GUIMARAES-SOUZA, NADIA K.. Stem Cell Applications in Regenerative Medicine for Kidney Diseases. STEM CELLS INTERNATIONAL, v. 2021, p. 3-pg., 2021-08-15. (17/18072-9)

BASTOS, ROSANA M. C.; SIMPLICIO-FILHO, ANTONIO; SAVIO-SILVA, CHRISTIAN; OLIVEIRA, LUIZ FELIPE, V; CRUZ, GIULIANO N. F.; SOUSA, ELIZA H.; NORONHA, IRENE L.; MANGUEIRA, CRISTOVAO L. P.; QUAGLIERINI-RIBEIRO, HELOISA; JOSEFI-ROCHA, GLEICE R.; et al. Fecal Microbiota Transplant in a Pre-Clinical Model of Type 2 Diabetes Mellitus, Obesity and Diabetic Kidney Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 7, p. 20-pg., 2022-04-01. (13/19560-6, 17/23195-2, 16/26263-6, 17/18072-9)

CHRISTIAN SÁVIO-SILVA; POLIANA EVELYN SOINSKI-SOUSA; MARIA THERESA A BALBY-ROCHA; ÁDYNA DE OLIVEIRA LIRA; ÉRIKA BEVILAQUA RANGEL. Mesenchymal stem cell therapy in acute kidney injury (AKI): review and perspectives. Revista da Associação Médica Brasileira, v. 66, p. s45-s54, 2020-01-13. (17/23195-2, 18/24562-1, 17/18072-9)

SAVIO-SILVA, CHRISTIAN; SOINSKI-SOUSA, POLIANA E.; SIMPLICIO-FILHO, ANTONIO; BASTOS, ROSANA M. C.; BEYERSTEDT, STEPHANY; RANGEL, ERIKA BEVILAQUA. Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 4, FEB 2021. (17/23195-2, 18/24562-1, 17/18072-9)

SAVIO-SILVA, CHRISTIAN; SOINSKI-SOUSA, POLIANA EVELYN; BALBY-ROCHA, MARIA THERESA A.; LIRA, ADYNA DE OLIVEIRA; RANGEL, ERIKA BEVILAQUA. Mesenchymal stem cell therapy in acute kidney injury (AKI): review and perspectives. Revista da Associação Médica Brasileira, v. 66, n. 1, p. S45-S54, 2020. (17/23195-2, 17/18072-9, 18/24562-1)