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Bioprospection of natural products in photodynamic therapy against microorganisms of medial and dental importance

Grant number: 18/18440-0
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2019
Effective date (End): February 29, 2020
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal Investigator:Fernanda Lourenção Brighenti
Grantee:Analú Barros de Oliveira
Home Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


The interest for natural photosensitizers has increased in the past years due to its ease to adhere or pass through cytoplasmic membrane and due to its potential in production reactive oxygen species. The aim of this study is to evaluate the in vitro potential of essential oils and plant extracts to be used in photodynamic therapy as monotherapy on Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Candida albicans and Cutibacterium acnes. First, antimicrobial photodynamic therapy will be carried out using the microorganisms in suspension at sub-inhibitory concentration of the plant material. Four treatment groups will be studied: negative control, plant material, light and photodynamic therapy (light + plant material). The plant material with the best results will be tested using the microorganisms in biofilms. The efficacy of the therapy will be evaluated by viable cell counting after the treatment. The evaluation of the production of reactive oxygen species and the evaluation of cytotoxicity will be performed in plant materials that present the best antimicrobial activity.Data will be analyzed with GraphPad Prism versão 3.02 at 5% significance.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANALÚ BARROS DE OLIVEIRA; TÚLIO MORANDIN FERRISSE; KARINA BORGES SALOMÃO; MARINA LINS MIRANDA; ANDREIA BUFALINO; FERNANDA LOURENÇÃO BRIGHENTI. Photobiomodulation in the treatment of xerostomia associated with hyposalivation in a pediatric patient with systemic scleroderma. Autopsy and Case Reports, v. 11, p. -, 2021.
MIRANDA, MARINA LINS; SILVA, BIANCA NUBIA SOUZA; SALOMAO, KARINA BORGES; DE OLIVEIRA, ANALU BARROS; GABBAI-ARMELIN, PAULO ROBERTO; BRIGHENTI, FERNANDA LOURENCAO. Effect of arginine on microorganisms involved in dental caries: a systematic literature review ofin vitrostudies. BIOFOULING, AUG 2020. Web of Science Citations: 0.
DE OLIVEIRA, ANALU BARROS; FERRISSE, TULIO MORANDIN; MARQUES, RAQUEL SOUZA; DE ANNUNZIO, SARAH RAQUEL; BRIGHENTI, FERNANDA LOURENCAO; FONTANA, CARLA RAQUEL. Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 14 JUL 2 2019. Web of Science Citations: 1.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
OLIVEIRA, Analú Barros de. Bioprospecção de produtos naturais em terapia fotodinâmica contra micro-organismos de interesse médico-odontológico. 2020. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Odontologia (Campus de Araraquara)..

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