Development of MRI and PET/PECT dual mode theranostic nanoagent

• Grant number: 19/02151-2
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: May 01, 2019
• End date: April 30, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Koiti Araki
• Grantee: Rodrigo Ken Kawassaki
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Nanotechnology is a powerful tool that is impacting all fields and has great potential for application in the medical field, especially in the treatment of diseases suchas Cancer. In this context, nanobiomaterials, nanomaterials conjugated to biomolecules, are being developed aiming the diagnosis and treatment of Cancer. Such nanobiomaterials must present colloidal stability in different biological systems, low toxicity against healthy cells and tissues, high selectivity towards the therapeutic target ssuch as tumors, thus minimizing eventual undesirable adverse effects. The Group is systematically developing the surface chemistry for multifunctionalization of nanoparticles and nanobiomaterials for application as MRI and PET contrast agents recently developed. However, some parameters must still must be adjusted to make them suitable for clinical use. Hence, the present PhD project is focused in the development of novel nanobiomaterials based on ultra small 3 nm diameter nanoparticles for Cancer diagnosis by imaging techniques such MRI and PET/SPECT, and eventually therapy (acting as antitumor drug carriers), thus realizing useful theranostic nanoagents. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DEDA, DAIANA K.; CARDOSO, ROBERTA M.; KAWASSAKI, RODRIGO K.; DE OLIVEIRA, ANDRE R.; TOMA, SERGIO H.; BAPTISTA, MAURICIO S.; ARAKI, KOITI. Cytotoxicity of Methotrexate Conjugated to Glycerol Phosphate Modified Superparamagnetic Iron Oxide Nanoparticles. Journal of Nanoscience and Nanotechnology, v. 21, n. 3, p. 1451-1461, MAR 2021. (18/21489-1, 19/02151-2)

KAWASSAKI, RODRIGO KEN; ROMANO, MARIANA; UCHIYAMA, MAYARA KLIMUK; CARDOSO, ROBERTA MANSINI; BAPTISTA, MAURIICIO S.; FARSKY, SANDRA H. P.; CHAIM, KHALLIL TAVERNA; GUIMARAES, ROBSON RAPHAEL; ARAKI, KOITI. Novel Gadolinium-Free Ultrasmall Nanostructured Positive Contrast for Magnetic Resonance Angiography and Imaging. Nano Letters, v. 23, n. 12, p. 9-pg., 2023-06-10. (09/54323-0, 18/21489-1, 19/02151-2)

KAWASSAKI, RODRIGO KEN; ROMANO, MARIANA; DIETRICH, NATASHA; ARAKI, KOITI. Titanium and Iron Oxide Nanoparticles for Cancer Therapy: Surface Chemistry and Biological Implications. FRONTIERS IN NANOTECHNOLOGY, v. 3, p. 24-pg., 2021-09-21. (18/21489-1, 19/02151-2)