| Grant number: | 19/07150-4 |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| Start date: | September 16, 2019 |
| End date: | September 15, 2020 |
| Field of knowledge: | Health Sciences - Medicine |
| Principal Investigator: | Hamilton Augusto Roschel da Silva |
| Grantee: | Tiago Peçanha de Oliveira |
| Supervisor: | David Andrew Low |
| Host Institution: | Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Institution abroad: | Liverpool John Moores University (LJMU), England |
| Associated to the scholarship: | 16/23319-0 - Cardiovascular autonomic dysfunction in rheumatoid arthritis patients: characterization, associations with the disease and effects of breaks in sedentary time, BP.PD |
Abstract Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by increased cardiovascular risk. This is partly due to the negative effects of sustained inflammation on vascular function. Recently, prolonged sitting time has been shown to cause further detrimental effects on vascular function in patients with RA. Therefore, it is important to verify the positive effects of breaking up prolonged sitting time on vascular function in these patients. The aim of this study will therefore be to assess the effects of breaking up prolonged sitting time with regular short bouts of light-intensity physical activity on micro-, macro- and cerebrovascular function in patients with RA. Using a randomized crossover design, 12 participants will attend the laboratory in the morning on two occasions, to perform baseline assessments of macro- (femoral flow-mediated dilation), micro- (leg skin blood flow response to reactive hyperemia) and cerebrovascular (middle cerebral artery blood velocity, CO2 reactivity and cerebral autoregulation) function and cognitive performance. Thereafter, subjects will be randomized to two interventions: 1) 4 h of uninterrupted sitting (SIT), and 2) 4 h of sitting interrupted by 3-min light-intensity walking every 30 min (WALK). Immediately after each intervention, participants will repeat the pre-intervention baseline measurements. A mixed-model analysis will be performed using intervention (SIT vs. WALK) and time (PRE vs. POST) as fixed factors, and subjects as a random factor. Post-hoc tests with Tukey's adjustment will be performed for multiple comparisons (SAS 9.2). Significance level will be set to Pd0.05. | |
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