Breaking up sedentary time in rheumatoid arthritis: effects on vascular function

• Grant number: 19/07150-4
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• Effective date (Start): September 16, 2019
• Effective date (End): September 15, 2020
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Hamilton Augusto Roschel da Silva
• Grantee: Tiago Peçanha de Oliveira
• Supervisor: David Andrew Low
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Research place: Liverpool John Moores University (LJMU), England
• Associated to the scholarship: 16/23319-0 - Cardiovascular autonomic dysfunction in rheumatoid arthritis patients: characterization, associations with the disease and effects of breaks in sedentary time, BP.PD

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by increased cardiovascular risk. This is partly due to the negative effects of sustained inflammation on vascular function. Recently, prolonged sitting time has been shown to cause further detrimental effects on vascular function in patients with RA. Therefore, it is important to verify the positive effects of breaking up prolonged sitting time on vascular function in these patients. The aim of this study will therefore be to assess the effects of breaking up prolonged sitting time with regular short bouts of light-intensity physical activity on micro-, macro- and cerebrovascular function in patients with RA. Using a randomized crossover design, 12 participants will attend the laboratory in the morning on two occasions, to perform baseline assessments of macro- (femoral flow-mediated dilation), micro- (leg skin blood flow response to reactive hyperemia) and cerebrovascular (middle cerebral artery blood velocity, CO2 reactivity and cerebral autoregulation) function and cognitive performance. Thereafter, subjects will be randomized to two interventions: 1) 4 h of uninterrupted sitting (SIT), and 2) 4 h of sitting interrupted by 3-min light-intensity walking every 30 min (WALK). Immediately after each intervention, participants will repeat the pre-intervention baseline measurements. A mixed-model analysis will be performed using intervention (SIT vs. WALK) and time (PRE vs. POST) as fixed factors, and subjects as a random factor. Post-hoc tests with Tukey's adjustment will be performed for multiple comparisons (SAS 9.2). Significance level will be set to Pd0.05.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SIECZKOWSKA, MENDES; SMAIRA, FABIANA INFANTE; MAZZOLANI, BRUNA CARUSO; GUALANO, BRUNO; ROSCHEL, HAMILTON; PECANHA, TIAGO. Efficacy of home-based physical activity interventions in patients with autoimmune rheumatic diseases: A systematic review and meta-analysis. SEMINARS IN ARTHRITIS AND RHEUMATISM, v. 51, n. 3, p. 576-587, JUN 2021. (19/07150-4, 19/14820-6, 17/13552-2, 16/23319-0, 19/14819-8, 19/15231-4)

PECANHA, TIAGO; GOESSLER, KARLA FABIANA; ROSCHEL, HAMILTON; GUALANO, BRUNO. Social isolation during the COVID-19 pandemic can increase physical inactivity and the global burden of cardiovascular disease. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 318, n. 6, p. H1441-H1446, JUN 2020. (17/13552-2, 19/07150-4, 19/18039-7)

PECANHA, TIAGO; BANNELL, DANIEL J.; SIECZKOWSKA, SOFIA MENDES; GOODSON, NICOLA; ROSCHEL, HAMILTON; SPRUNG, VICTORIA S.; LOW, DAVID A.. Effects of physical activity on vascular function in autoimmune rheumatic diseases: a systematic review and meta-analysis. RHEUMATOLOGY, v. 60, n. 7, p. 3107-3120, JUL 2021. (19/15231-4, 19/07150-4, 16/23319-0)

PECANHA, TIAGO; MEIRELES, KAMILA; PINTO, ANA JESSICA; NUNES REZENDE, DIEGO AUGUSTO; IRAHA, AMANDA YURI; MAZZOLANI, BRUNA CARUSO; SMAIRA, FABIANA INFANTE; KLUSER SALES, ALLAN ROBSON; BONFIGLIOLI, KARINA; DE SA-PINTO, ANA LUCIA; et al. Increased sympathetic and haemodynamic responses to exercise and muscle metaboreflex activation in post-menopausal women with rheumatoid arthritis. JOURNAL OF PHYSIOLOGY-LONDON, v. 599, n. 3, NOV 2020. (19/14819-8, 15/26937-4, 17/13552-2, 14/11671-6, 19/07150-4)