Engineered biomaterials based on coconut oil and natural polymers: new ways to develop added-value biomedical products

• Grant number: 19/12665-3
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: July 01, 2019
• End date: June 30, 2022
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Agreement: Fundação para a Ciência e a Tecnologia (FCT)
• Principal Investigator: Watson Loh
• Grantee: Denise Gradella Villalva
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 18/08045-7 - Engineered biomaterials based on coconut oil and natural polymers: new ways to develop added-value biomedical products, AP.R

Abstract

This project aims at exploring organized structures formed by mixtures of lipids or fatty acids, such as coconut oil, and natural polyelectrolytes such as chitosan, though not restricted to these components, to obtain responsive systems for biomedical or food applications. Structural characterization involving techniques such as light and X-ray scattering is envisioned accompanied by investigation on incorporation and release of active compounds, including the possibility of in-vivo experiments, with control by external triggers such as temperature, pH, ionic strength or others.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VILLALVA, DENISE GRADELLA; FRANCA, CARLA GIOMETTI; LOH, WATSON. Characterization of cubosomes immobilized in hydrogels of hyaluronic acid and their use for diclofenac controlled delivery. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 212, p. 9-pg., 2022-02-01. (18/08045-7, 15/25406-5, 19/12665-3)

SILVA, SIMONE S.; RODRIGUES, LUISA C.; FERNANDES, EMANUEL M.; DA COSTA, DIANA SOARES; VILLALVA, DENISE G.; LOH, WATSON; REIS, RUI L.. Chitosan/Virgin-Coconut-Oil-Based System Enriched with Cubosomes: A 3D Drug-Delivery Approach. MARINE DRUGS, v. 21, n. 7, p. 15-pg., 2023-07-01. (19/12665-3, 21/12071-6, 15/25406-5, 18/08045-7)