Effects of basiliximab upon airway mucus production of rats

• Grant number: 18/17924-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): August 01, 2019
• Effective date (End): September 30, 2020
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Rogerio Pazetti
• Grantee: Júlia Helena Rodrigues de Castro
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

To complement the immunosuppressive regimens, at the time of lung transplantation or in the previous postoperative period, many centers are using as induction therapy the drug basiliximab which is an antibody antagonists of the Interleukin-2 receptor. It is known that the main cause of death in the first month after lung transplantation is infectious, coinciding with the same period of greater dysfunction of the mucociliary epithelium. This acute dysfunction incapacitates the mucociliary apparatus of protecting and purifying the airways, increasing the possibility of infections. Due to the specificity of basiliximab and a mild adverse effect profile, we believe that this drug has no effect on the mucociliary apparatus. To test this hypothesis, we will use 80 male rats distributed in four groups, according to the type of treatment, each with two subgroups, according to the treatment time (7 or 15 days). Group 1: saline solution, Group 2: basiliximab, Group 3: tacrolimus, mycophenolate sodium and predinosolone and Group 4: tacrolimus, mycophenolate sodium, predinosolone and basiliximab. In the four groups, the bronchi will be evaluated for the frequency of ciliary beat, mucociliary transport velocity, histology and morphometry.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CORREIA, ARISTIDES TADEU; DE ALMEIDA, FRANCINE MARIA; AUGUSTO-COTTET, MARCIA CRISTINA; NOLASCO, PATRICIA; ALVES BENTO, AFONSO SILVA; MATSUSHIMA HIRANO, HUGO KENJI; RIBEIRO DE SOUZA, MARIA CECILIA; DOS SANTOS, ELIZABETE SILVA; RODRIGUES DE CASTRO, JULIA HELENA; MATSUDA, MONIQUE; et al. Basiliximab Does Not Impair Airway Mucociliary Clearance of Rats. Inflammation, v. N/A, p. 13-pg., 2022-06-17. (12/09839-0, 18/17708-0, 14/17525-1, 18/17924-4, 12/24085-2, 12/18784-5)