Effects of basiliximab associated or not with triple therapy on airway mucociliary clearance of rats: experimental study

• Grant number: 12/18784-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): March 01, 2013
• Effective date (End): February 28, 2015
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Rogerio Pazetti
• Grantee: Afonso da Silva Alves Bento
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

To complement the immunosuppression regimens, at the time the lung transplantation or early postoperative period many centers are using basiliximab as induction therapy which is an antibody antagonist of the Interleukin-2 receptor. It is known that infection is the main cause of death in the first month after lung transplantation, coinciding with the same period of greater dysfunction of mucociliary epithelium. That acute dysfunction disables the mucociliary apparatus to protect and purify the air, increasing the possibility of infection. Because of the specificity of basiliximab and a mild adverse effect profile, we believe that this drug does not have any effect on the mucociliary system. To test this hypothesis, we will use 120 male rats. The animals will be divided into four groups, each one with three subgroups, based upon the date of sacrifice (7, 15, or 30 days): Group 1: saline; Group 2: basiliximab; Group 3: tacrolimus, mycophenolate sodium, and prednisone; and Group 4: tacrolimus, mycophenolate sodium, prednisone, and basiliximab. Ciliary beat frequency, mucociliary transport velocity, histology, and morphometry of airways will be evaluated.(AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CORREIA, ARISTIDES TADEU; DE ALMEIDA, FRANCINE MARIA; AUGUSTO-COTTET, MARCIA CRISTINA; NOLASCO, PATRICIA; ALVES BENTO, AFONSO SILVA; MATSUSHIMA HIRANO, HUGO KENJI; RIBEIRO DE SOUZA, MARIA CECILIA; DOS SANTOS, ELIZABETE SILVA; RODRIGUES DE CASTRO, JULIA HELENA; MATSUDA, MONIQUE; et al. Basiliximab Does Not Impair Airway Mucociliary Clearance of Rats. Inflammation, v. N/A, p. 13-pg., 2022-06-17. (12/09839-0, 18/17708-0, 14/17525-1, 18/17924-4, 12/24085-2, 12/18784-5)