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Synthesis of ordered mesoporous silica with different structures and morphologies

Grant number: 19/12301-1
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): August 01, 2019
Effective date (End): May 31, 2023
Field of knowledge:Physical Sciences and Mathematics - Physics - Condensed Matter Physics
Principal Investigator:Marcia Carvalho de Abreu Fantini
Grantee:Pedro Leonidas Oseliero Filho
Host Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:17/17844-8 - Nanostructured silica as a protective vehicle for vaccines and biomolecules, AP.TEM
Associated scholarship(s):20/13204-7 - The role of mesoporous silica morphology in the incorporation of diphtheria and tetanus anatoxins: potential adjuvants for oral vaccines, BE.EP.PD

Abstract

In this postdoctoral project it is proposed to synthesize ordered mesoporous silicas (OMSs) and analyze the encapsulation and release of antigens in an oral formulation of poly-vaccines. The capability of encapsulation in these new silicas will be tested for diphtheria and tetanus anatoxins. The release process will be analyzed in samples without and with a polymeric coverage resistant to acidic pH.

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Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LOSITO, DANILO WAISMANN; DE ARAUJO, DANIELE RIBEIRO; NONATO BEZZON, VINICIUS DANILO; OSELIERO FILHO, PEDRO LEONIDAS; AFFONSO FONSECA, FERNANDO LUIZ; CHAGAS, CAMILA DOS SANTOS; BARBOSA, EMERSON; PINTO OLIVEIRA, CRISTIANO LUIS; DE ABREU FANTINI, MARCIA CARVALHO; FERREIRA, FABIO FURLAN; et al. esoporous Silica-Fe3O4 Nanoparticle Composites as Potential Drug Carrier. ACS APPLIED NANO MATERIALS, v. 4, n. 12, p. 13363-13378, . (20/13204-7, 14/50869-6, 17/17844-8, 18/11990-5, 19/12301-1)
OSELIERO FILHO, PEDRO LEONIDAS; GERBELLI, BARBARA BIANCA; FORNASIER, FRANCCESCA; CHAVES FILHO, ADRIANO B.; YOSHINAGA, MARCOS YUKIO; MIYAMOTO, SAYURI; MORTARA, LAURA; LACERDA, CAROLINE DUTRA; CUCCOVIA, IOLANDA MIDEA; PIMENTEL, ANDRE SILVA; et al. Structure and Thermotropic Behavior of Bovine- and Porcine-Derived Exogenous Lung Surfactants. Langmuir, v. 36, n. 48, p. 14514-14529, . (16/24531-3, 19/12301-1, 18/05888-3, 14/50983-3, 18/16092-5)
LOSITO, DANILO W.; LOPES, PATRICIA S.; UEOKA, ANDREZA R.; FANTINI, MARCIA C. A.; OSELIERO FILHO, PEDRO LEONIDAS; ANDREO-FILHO, NEWTON; MARTINS, TEREZA S.. Biocomposites based on SBA-15 and papain: Characterization, enzymatic activity and cytotoxicity evaluation. Microporous and Mesoporous Materials, v. 325, . (19/12301-1, 17/26618-1, 17/17844-8, 16/22916-5, 20/13204-7, 19/08582-5)
TREZENA, ARYENE GOES; OSELIERO FILHO, PEDRO LEONIDAS; DA SILVA, LUIS CARLOS CIDES; OLIVEIRA, CRISTIANO LUIS PINTO; LOPES, JOSE LUIZ DE SOUZA; ANTONIO, NAYARA DA SILVA; DETTMANN, VIKTOR FONSECA BARBOSA; AKAMATSU, MILENA APETITO; MARTINS, TEREZA DA SILVA; RIBEIRO, ORLANDO GARCIA; et al. Adjuvant effect of mesoporous silica SBA-15 on anti-diphtheria and anti-tetanus humoral immune response. BIOLOGICALS, v. 80, p. 9-pg., . (17/17844-8, 20/13204-7, 19/12301-1)
MARTINEZ, RENATA MILIANI; OSELIERO FILHO, PEDRO LEONIDAS; GERBELLI, BARBARA BIANCA; MAGALHAES, WAGNER VIDAL; VELASCO, MARIA VALERIA ROBLES; DA SILVA LANNES, SUZANA CAETANO; DE OLIVEIRA, CRISTIANO LUIS PINTO; ROSADO, CATARINA; BABY, ANDRE ROLIM. Influence of the Mixtures of Vegetable Oil and Vitamin E over the Microstructure and Rheology of Organogels. GELS, v. 8, n. 1, . (16/24531-3, 20/02192-8, 19/16169-0, 19/12301-1, 18/05888-3, 20/13204-7)
SOUZA, BRUNA B. S.; LOURENCO, THIAGO C.; GERBELLI, BARBARA B.; OSELIERO FILHO, PEDRO L.; OLIVEIRA, CRISTIANO L. P.; MIRANDA, ANTONIO; DA SILVA, EMERSON R.. A biophysical study of DNA condensation mediated by histones and protamines. JOURNAL OF MOLECULAR LIQUIDS, v. 368, p. 11-pg., . (20/13204-7, 18/05888-3, 19/12301-1, 20/02192-8)
GERBELLI, BARBARA B.; FILHO, PEDRO L. O.; CORTEZ, BRUNA; SODRE, PEDRO T.; COUTINHO-NETO, MAURICIO D.; HAMLEY, IAN W.; SEITSONEN, JANI; ALVES, WENDEL A.. Interaction between glyphosate pesticide and amphiphilic peptides for colorimetric analysis. NANOSCALE ADVANCES, v. 4, n. 17, p. 8-pg., . (14/50867-3, 17/02317-2, 20/13204-7, 18/05888-3, 19/12301-1, 20/02192-8)

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