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Involvement of MHC I, TLR2 and TLR4 in the synaptic plasticity and functional reovery following crushing of spinal ventral roots in mice

Grant number: 19/02714-7
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): August 01, 2019
Effective date (End): July 31, 2022
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal researcher:Alexandre Leite Rodrigues de Oliveira
Grantee:Luciana Politti Cartarozzi
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:18/05006-0 - Sensorimotor recovery following spinal root axotomy: use of different experimental approaches, AP.TEM

Abstract

Peripheral nerve lesions are followed by an increase in expression of immune molecules, such as the Major Histocompatibility Complex Class I (MHC-I). The MHC-I upregulation is directly related to the synaptic plasticity process, glial cell activity modulation and functional recovery. Knockout mice for the MHC-I obligatory chain ²2 microglobulin (²2m), show increased reduction in synaptic density and deficit in axonal regeneration after peripheral lesion. There are other receptors that share MHC-I domains, such as paired-immunoglobulin receptors (PIR-A and B) and Killer-cell immunoglobulin-like receptors (KIR), specifically KIR3DL2. Such receptors have an inhibitory role in axonal growth after lesion. In the same way, Toll-like receptors 2 and 4 (TLR 2 and TLR 4) are activated in the spinal cord after lesion, relating TLR 4 to mediate synaptic stability and TLR 2, synaptic elimination. The present project aims to evaluate the synaptic plasticity process and functional recovery after ventral root crush (VRC) in knockout mice for ²2m, TLR 4 and TLR 2, correlating morphological findings with glial reactivity and expression of proteins related to the signaling pathways involving immune system components.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARTAROZZI, LUCIANA POLITTI; PEREZ, MATHEUS; FERNANDES, GABRIEL GRIPP; CHIAROTTO, GABRIELA BORTOLANCA; LUZO, ANGELA CRISTINA MALGEIROS; CAMPOS, ALLINE CRISTINA; KIRCHHOFF, FRANK; DE OLIVEIRA, ALEXANDRE LEITE RODRIGUES. europrotection and gliosis attenuation by intravenous application of human mesenchymal stem cells (hMSC) following ventral root crush in mic. Molecular and Cellular Neuroscience, v. 118, JAN 2022. Web of Science Citations: 0.
PEREZ, MATHEUS; CARTAROZZI, LUCIANA POLITTI; CHIAROTTO, GABRIELA BORTOLANCA; GUIMARAES, FRANCISCO SILVEIRA; DE OLIVEIRA, ALEXANDRE LEITE RODRIGUES. Short and long-term neuroprotective effects of cannabidiol after neonatal peripheral nerve axotomy. Neuropharmacology, v. 197, OCT 1 2021. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.