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Expression of long non-coding RNAs in patients infected with cutaneous leishmaniasis

Grant number: 19/13541-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2019
Effective date (End): November 30, 2020
Field of knowledge:Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
Principal researcher:Flavia Lombardi Lopes
Grantee:Mariana Cordeiro Almeida
Home Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

Leishmaniasis is a parasitic disease considered a serious public health problem, being endemic in 98 countries. The causative agents of the disease are protozoa of the genus Leishmania. According to the clinical manifestations, the disease is classified in two types: tegumentary leishmaniasis (LT) and visceral leishmaniasis (VL). LT is the most common type of disease, and encompasses cutaneous and mucocutaneous forms. American Cutaneous Leishmaniasis (LTA) is responsible for Localized Cutaneous Leishmaniasis (LCL), the simplest disease form, and also for more severe forms such as Mucocutaneous Leishmaniasis (CML). In Brazil, LTA cases are registered in all regions of the country. From 3 to 5% of LCL cases progress to CML. Physiological mechanisms are regulated mainly by DNA that is influenced by a set of processes called epigenetic mechanisms, which guarantee a time and tissue-specific regulation of gene expression. Long non-coding RNAs (lncRNAs) present diverse functions within cellular mechanisms such as regulation of gene expression, recruitment of transcriptional factors, besides regulatory action during pathologies and activation of immune response. This work aims to process data obtained in previous studies to elucidate the expression of annotated and differentially expressed lncRNAs in patients infected with tegumentary leishmaniasis who present primary lesions and eventually develop mucocutaneous lesions.

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