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Development of sustainable and biomimetics methodologies for extraction of bioactive compounds from chamomile

Grant number: 19/16991-2
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2019
Effective date (End): September 30, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Daniel Rinaldo
Grantee:Lucas de Melo Trentin
Home Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil

Abstract

The extracts of Matricaria chamomilla L. have remarkable pharmaceutical uses. Being pediatrics an important area of application of these, because of its soothing, antispasmodic, anti-inflammatory and analgesic activities. However, the use of extracts based on hydroalcoholic solvents should be avoided due to possible complications caused by ingestion of toxic solvents, such as alcohol, by infants and children. Because of these facts, this project proposes the preparation of chamomile extracts from eutectic mixtures of natural molecules called Natural Deep Eutectic Solvent (NADES). NADES will consist of non-toxic natural molecules used as food and will be prepared via microwave. Extractions will also be performed by microwave, but using experimental planning to optimize the best extraction condition through a multiparametric approach. To optimize the extractions will be evaluated the quantities extracted from the markers of Matricaria chamomilla L. using High Performance Liquid Chromatography coupled with photodiode array detector (HPLC-DAD). In addition to the NADES a toxicity, the HPLC elution method will be composed of water and bioethanol, sustainable alternatives with lower mobile phase toxicity, so that the whole process meets the principles of Green Chemistry and has a lower cost when compared to the conventional methods of literature, and can be replicated in laboratories and small and medium industries.