Influence of gender and time on cardiac remodeling induced by vitamin D supplementation

• Grant number: 19/15581-5
• Support Opportunities: Scholarships in Brazil - Master
• Start date: October 01, 2019
• End date: April 30, 2021
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Sergio Alberto Rupp de Paiva
• Grantee: Matheus Augusto Callegari
• Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Vitamin D deficiency has been considered a public health problem. Concerns about this deficiency increase every day due to new findings that associate it with the development of chronic diseases, including cardiovascular diseases. Because of this, several professionals have been encouraging vitamin D supplementation indiscriminately. However, recent studies have shown that vitamin D has biphasic dose-response in cardiovascular pathophysiology, with both deficiencies and excesses being detrimental. In a study conducted in our laboratory, it was observed that the supplementation of excessive but not hypercalcemic doses of vitamin D resulted in a continuous process of cardiac aggression which was dose and time dependent. However, VitD metabolism appears to be different for both men and women. Therefore, further studies are needed to assess whether these changes also occur in females. The aim of this study is to evaluate whether vitamin D supplementation leads to different cardiac changes in male and female rats and whether these changes are time dependent. 72 female Wistar rats and 72 female Wistar rats will be divided into 12 groups: Control group male (CM) and female (CF) - formed by 12 animals in each group that will receive the ration without supplementation of cholecalciferol for 20, 40 and 60 days ; VitD10 male (VD10-M) and female (VD10-F) groups - formed by 12 animals each group receiving the supplementation of 10,000 IU of cholecalciferol / kg of feed for 20, 40 and 60 days. After this period, the animals will be euthanized and submitted to the collection of biological material for analysis of biochemical, cellular, molecular, structure and function alterations. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CALLEGARI, Matheus Augusto. Influence of sex and time on cardiac remodeling induced by vitamin D supplementation. 2021. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Medicina. Botucatu Botucatu.