Synaptic plasticity in neuronal networks

• Grant number: 20/04624-2
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: May 01, 2020
• End date: September 30, 2024
• Field of knowledge: Physical Sciences and Mathematics - Physics
• Principal Investigator: Iberê Luiz Caldas
• Grantee: Paulo Ricardo Protachevicz
• Host Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 18/03211-6 - Non linear dynamics, AP.TEM
• Associated scholarship(s): 23/12863-5 - Synchronization in neuronal networks with long-term synaptic plasticity, BE.EP.PD 22/05153-9 - Neuronal networks with short-term plasticity, BE.EP.PD

Abstract

In this project will be investigated the influence of synaptic plasticity to obtain synchronous and asynchronous firing patterns. The proposal foresee study of long and short term plasticity, evaluated for individual and conjoint case. Although these two types of plasticity act at the same time, the influence of each one occurs at different time scales. This study is justified due to the fact that abnormal synchronized states of activities are directly related to several neurological diseases such as Parkinson's Disease and Epilepsy. Otherwise, normal firing patterns of synchronization have been identified as a fact that benefits the formation of memories. Thus, to evaluate the effect of plasticity, we will have the dynamics of neuronal network also studied under the influence of factors such as (i) the network topology; (ii) the external signal inputs in the network; (iii) the time delay; and (iv) the firing frequency. Neuronal models such as Hodgkin-Huxley and adaptive exponential integrate-and-fire, among others, can be conveniently used in this study. (AU

Scientific publications

(28)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

LAMEU, EWANDSON L.; BORGES, FERNANDO S.; LAROSZ, KELLY C.; PROTACHEVICZ, PAULO R.; ANTONOPOULOS, CHRIS G.; MACAU, ELBERT E. N.; BATISTA, ANTONIO M.. Short-term and spike-timing-dependent plasticity facilitate the formation of modular neural networks. COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION, v. 96, MAY 2021. (15/50122-0, 17/13502-5, 16/23398-8, 15/07311-7, 17/18977-1, 17/20920-8, 20/04624-2, 11/19296-1)

PROTACHEVICZ, PAULO R.; IAROSZ, KELLY C.; CALDAS, IBERE L.; ANTONOPOULOS, CHRIS G.; BATISTA, ANTONIO M.; KURTHS, JURGEN. Influence of Autapses on Synchronization in Neural Networks With Chemical Synapses. FRONTIERS IN SYSTEMS NEUROSCIENCE, v. 14, NOV 30 2020. (15/50122-0, 20/04624-2)

HANSEN, MATHEUS; PROTACHEVICZ, PAULO R.; IAROSZ, KELLY C.; CALDAS, IBERE L.; BATISTA, ANTONIO; MACAU, ELBERT E. N.. Dynamics of uncoupled and coupled neurons under an external pulsed current. CHAOS SOLITONS & FRACTALS, v. 155, p. 10-pg., 2022-02-01. (18/03211-6, 20/04624-2, 19/09150-1, 15/50122-0)

TROBIA, JOSE; TIAN, KUN; BATISTA, ANTONIO M.; GREBOGI, CELSO; REN, HAI-PENG; SANTOS, MOISES S.; PROTACHEVICZ, PAULO R.; BORGES, FERNANDO S.; SZEZECH, JR., JOSE D.; VIANA, RICARDO L.; et al. Mathematical model of brain tumour growth with drug resistance. COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION, v. 103, DEC 2021. (18/03211-6, 20/04624-2, 17/18977-1, 15/07311-7)

PROTACHEVICZ, PAULO RICARDO; BORGES, FERNANDO DA SILVA; BATISTA, ANTONIO MARCOS; BAPTISTA, MURILO DA SILVA; CALDAS, IBERE LUIZ; MACAU, ELBERT EINSTEIN NEHRER; LAMEU, EWANDSON LUIZ. Plastic neural network with transmission delays promotes equivalence between function and structure. CHAOS SOLITONS & FRACTALS, v. 171, p. 9-pg., 2023-04-26. (20/04624-2, 22/05153-9, 16/23398-8, 22/13761-9, 18/03211-6, 17/13502-5)

PROTACHEVICZ, PAULO R.; HANSEN, MATHEUS; IAROSZ, KELLY C.; CALDAS, IBERE L.; BATISTA, ANTONIO M.; KURTHS, JURGEN. Emergence of Neuronal Synchronisation in Coupled Areas. FRONTIERS IN COMPUTATIONAL NEUROSCIENCE, v. 15, APR 22 2021. (19/09150-1, 20/04624-2, 15/50122-0, 18/03211-6)

YANG, CHAO; SANTOS, MOISES S.; PROTACHEVICZ, PAULO R.; DOS REIS, PATRICIO D. C.; IAROSZ, KELLY C.; CALDAS, IBERE L.; BATISTA, ANTONIO M.. Chimera states induced by spike timing-dependent plasticity in a regular neuronal network. AIP ADVANCES, v. 12, n. 10, p. 6-pg., 2022-10-01. (18/03211-6, 20/04624-2)

PIROLA, JOAO PEDRO; DEFOREST, PAIGE; PROTACHEVICZ, PAULO R.; FONTENAS, LAURA; FERREIRA, RICARDO F.; PENA, RODRIGO F. O.. Astrocytic signatures in neuronal activity: a machine learning-based identification approach. COGNITIVE NEURODYNAMIC, v. 19, n. 1, p. 20-pg., 2025-12-01. (23/09094-0, 23/15585-6, 20/04624-2)

PROTACHEVICZ, PAULO R.; BATISTA, ANTONIO M.; CALDAS, IBERE L.; BAPTISTA, MURILO S.. Analytical solutions for the short-term plasticity. CHAOS SOLITONS & FRACTALS, v. 181, p. 9-pg., 2024-02-29. (22/05153-9, 22/13761-9, 20/04624-2)

GABRICK, ENRIQUE C.; BRUGNAGO, EDUARDO L.; DE MORAES, ANA L. R.; PROTACHEVICZ, PAULO R.; DA SILVA, SIDNEY T.; BORGES, FERNANDO S.; CALDAS, IBERE L.; BATISTA, ANTONIO M.; KURTHS, JUERGEN. Control, bi-stability, and preference for chaos in time-dependent vaccination campaign. Chaos, v. 34, n. 9, p. 13-pg., 2024-09-01. (20/04624-2, 18/03211-6, 23/12863-5, 21/12232-0, 22/13761-9)

BORGES, FERNANDO S.; PROTACHEVICZ, PAULO R.; SOUZA, DIOGO L. M.; BITTENCOURT, CONRADO F.; GABRICK, ENRIQUE C.; BENTIVOGLIO, LUCAS E.; SZEZECH JR, JOSE D.; BATISTA, ANTONIO M.; CALDAS, IBERE L.; DURA-BERNAL, SALVADOR; et al. The Roles of Potassium and Calcium Currents in the Bistable Firing Transition. BRAIN SCIENCES, v. 13, n. 9, p. 17-pg., 2023-09-01. (21/12232-0, 18/03211-6, 22/13761-9, 20/04624-2)

SOUZA, DIOGO L. M.; GABRICK, ENRIQUE C.; PROTACHEVICZ, PAULO R.; BORGES, FERNANDO S.; TROBIA, JOSE; IAROSZ, KELLY C.; BATISTA, ANTONIO M.; CALDAS, IBERE L.; LENZI, ERVIN K.. Adaptive exponential integrate-and-fire model with fractal extension. Chaos, v. 34, n. 2, p. 9-pg., 2024-02-01. (18/03211-6, 23/12863-5, 20/04624-2)

SANTOS, MOISES S.; PROTACHEVICZ, PAULO R.; CALDAS, IBERE L.; IAROSZ, KELLY C.; VIANA, RICARDO L.; SZEZECH, JOSE D.; DE SOUZA, SILVIO L. T.; BATISTA, ANTONIO M.. Spiral wave chimera states in regular and fractal neuronal networks. JOURNAL OF PHYSICS-COMPLEXITY, v. 2, n. 1, p. 7-pg., 2021-06-01. (18/03211-6, 20/04624-2)

GABRICK, ENRIQUE C.; SAYARI, ELAHEH; PROTACHEVICZ, PAULO R.; SZEZECH JR, JOSE D.; IAROSZ, KELLY C.; DE SOUZA, SILVIO L. T.; ALMEIDA, ALEXANDRE C. L.; VIANA, RICARDO L.; CALDAS, IBERE L.; BATISTA, ANTONIO M.. Unpredictability in seasonal infectious diseases spread. CHAOS SOLITONS & FRACTALS, v. 166, p. 8-pg., 2022-12-13. (22/05153-9, 18/03211-6, 20/04624-2)

BORGES, F. S.; GABRICKC, E. C.; PROTACHEVICZ, P. R.; HIGA, G. S. V.; LAMEU, E. L.; RODRIGUEZ, P. X. R.; FERRAZ, M. S. A.; SZEZECH JR, J. D.; BATISTA, A. M.; KIHARA, A. H.. Intermittency properties in a temporal lobe epilepsy model. Epilepsy & Behavior, v. 139, p. 9-pg., 2023-01-16. (22/09277-4, 16/16148-5, 22/13761-9, 19/17892-8, 17/18977-1, 19/15024-9, 20/04624-2, 11/19296-1, 15/07311-7)

MUGNAINE, MICHELE; GABRICK, ENRIQUE C.; PROTACHEVICZ, PAULO R.; IAROSZ, KELLY C.; DE SOUZA, SILVIO L. T.; ALMEIDA, ALEXANDRE C. L.; BATISTA, ANTONIO M.; CALDAS, IBERE L.; SZEZECH, JOSE D., JR.; VIANA, RICARDO L.. Control attenuation and temporary immunity in a cellular automata SEIR epidemic model. CHAOS SOLITONS & FRACTALS, v. 155, p. 9-pg., 2022-02-01. (18/03211-6, 20/04624-2)

PROTACHEVICZ, P. R.; BONIN, C. A.; IAROSZ, K. C.; CALDAS, I. L.; BATISTA, A. M.. Large coefficient of variation of inter-spike intervals induced by noise current in the resonate-and-fire model neuron. COGNITIVE NEURODYNAMIC, v. N/A, p. 10-pg., 2022-02-28. (18/03211-6, 20/04624-2)

HANSEN, MATHEUS; PROTACHEVICZ, PAULO R.; IAROSZ, KELLY C.; CALDAS, IBERE L.; BATISTA, ANTONIO M.; MACAU, ELBERT E. N.. The effect of time delay for synchronisation suppression in neuronal networks. CHAOS SOLITONS & FRACTALS, v. 164, p. 10-pg., 2022-11-01. (18/03211-6, 20/04624-2, 19/09150-1, 15/50122-0)

BOARETTO, BRUNO R. R.; PROTACHEVICZ, PAULO R.; HANSEN, MATHEUS; MEDRANO-T, RENE O.; MACAU, ELBERT E. N.; GREBOGI, CELSO. Complex bifurcation structures in a Hodgkin-Huxley model of thermally sensitive neurons under periodic perturbation. PHYSICAL REVIEW E, v. 111, n. 5, p. 6-pg., 2025-05-15. (24/06718-5, 21/09839-0, 23/12863-5, 22/05153-9, 20/04624-2, 23/16273-8)

BORGES, FERNANDO S.; PROTACHEVICZ, PAULO R.; SOUZA, DIOGO L. M.; BITTENCOURT, CONRADO F.; GABRICK, ENRIQUE C.; BENTIVOGLIO, LUCAS E.; SZEZECH JR, JOSE D.; BATISTA, ANTONIO M.; CALDAS, IBERE L.; DURA-BERNAL, SALVADOR; et al. The Roles of Potassium and Calcium Currents in the Bistable Firing Transition (vol 13, 1347, 2023). BRAIN SCIENCES, v. 14, n. 8, p. 1-pg., 2024-08-01. (21/12232-0, 18/03211-6, 22/13761-9, 20/04624-2)

PALUDO SILVEIRA, JOAO ANTONIO; PROTACHEVICZ, PAULO RICARDO; VIANA, RICARDO LUIZ; BATISTA, ANTONIO MARCOS. Effects of burst-timing-dependent plasticity on synchronous behaviour in neuronal network. Neurocomputing, v. 436, p. 126-135, MAY 14 2021. (20/04624-2)

GABRICK, ENRIQUE C.; PROTACHEVICZ, PAULO R.; BATISTA, ANTONIO M.; IAROSZ, KELLY C.; DE SOUZA, SILVIO L. T.; ALMEIDA, ALEXANDRE C. L.; SZEZECH JR, JOSE D.; MUGNAINE, MICHELE; CALDAS, IBERE L.. Effect of two vaccine doses in the SEIR epidemic model using a stochastic cellular automaton. PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, v. 597, p. 12-pg., 2022-03-26. (20/04624-2, 18/03211-6)

DA SILVA, SIDNEY T.; GABRICK, ENRIQUE C.; PROTACHEVICZ, PAULO R.; IAROSZ, KELLY C.; CALDAS, IBERE L.; BATISTA, ANTONIO M.; KURTHS, JUERGEN. When climate variables improve the dengue forecasting: a machine learning approach. European Physical Journal-Special Topics, v. N/A, p. 15-pg., 2024-06-17. (22/13761-9, 18/03211-6, 23/12863-5, 20/04624-2)

SOUZA, DIOGO L. M.; BORGES, FERNANDO S.; GABRICK, ENRIQUE C.; BENTIVOGLIO, LUCAS E.; PROTACHEVICZ, PAULO R.; DOS SANTOS, VAGNER; VIANA, RICARDO L.; CALDAS, IBERE L.; IAROSZ, KELLY C.; BATISTA, ANTONIO M.; et al. Spiral wave dynamics in a neuronal network model. JOURNAL OF PHYSICS-COMPLEXITY, v. 5, n. 2, p. 10-pg., 2024-06-01. (22/04251-7, 18/03211-6, 20/04624-2)

GABRICK, ENRIQUE C.; PROTACHEVICZ, PAULO R.; LENZI, ERVIN K.; SAYARI, ELAHEH; TROBIA, JOSE; LENZI, MARCELO K.; BORGES, FERNANDO S.; CALDAS, IBERE L.; BATISTA, ANTONIO M.. Fractional Diffusion Equation under Singular and Non-Singular Kernel and Its Stability. FRACTAL AND FRACTIONAL, v. 7, n. 11, p. 17-pg., 2023-11-01. (22/13761-9, 20/04624-2)

BOARETTO, BRUNO R. R.; PROTACHEVICZ, PAULO R.; HANSEN, MATHEUS; OLIVEIRA, JONAS; ANDREANI, ALEXANDRE C.; MACAU, ELBERT E. N.. Phase synchronization in a sparse network of randomly connected neurons under the effect of Poissonian spike inputs. Chaos, v. 33, n. 12, p. 11-pg., 2023-12-01. (22/05153-9, 21/09839-0, 18/03211-6, 20/04624-2)

GABRICK, ENRIQUE C.; PROTACHEVICZ, PAULO R.; SOUZA, DIOGO L. M.; TROBIA, JOSE; SAYARI, ELAHEH; BORGES, FERNANDO S.; LENZI, MARCELO K.; CALDAS, IBERE L.; BATISTA, ANTONIO M.; LENZI, ERVIN K.. Transient Dynamics of a Fractional Fisher Equation. FRACTAL AND FRACTIONAL, v. 8, n. 3, p. 12-pg., 2024-03-01. (22/13761-9, 20/04624-2)

PROTACHEVICZ, PAULO R.; BORGES, FERNANDO S.; IAROSZ, KELLY C.; BAPTISTA, MURILO S.; LAMEU, EWANDSON L.; HANSEN, MATHEUS; CALDAS, IBERE L.; SZEZECH, JOSE D., JR.; BATISTA, ANTONIO M.; KURTHS, JUERGEN. Influence of Delayed Conductance on Neuronal Synchronization. FRONTIERS IN PHYSIOLOGY, v. 11, p. 9-pg., 2020-09-03. (15/50122-0, 20/04624-2, 15/07311-7, 16/23398-8, 17/18977-1, 18/03211-6)