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Synaptic plasticity in neuronal networks

Grant number: 20/04624-2
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): May 01, 2020
Effective date (End): April 30, 2022
Field of knowledge:Physical Sciences and Mathematics - Physics
Principal Investigator:Iberê Luiz Caldas
Grantee:Paulo Ricardo Protachevicz
Home Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:18/03211-6 - Non linear dynamics, AP.TEM

Abstract

In this project will be investigated the influence of synaptic plasticity to obtain synchronous and asynchronous firing patterns. The proposal foresee study of long and short term plasticity, evaluated for individual and conjoint case. Although these two types of plasticity act at the same time, the influence of each one occurs at different time scales. This study is justified due to the fact that abnormal synchronized states of activities are directly related to several neurological diseases such as Parkinson's Disease and Epilepsy. Otherwise, normal firing patterns of synchronization have been identified as a fact that benefits the formation of memories. Thus, to evaluate the effect of plasticity, we will have the dynamics of neuronal network also studied under the influence of factors such as (i) the network topology; (ii) the external signal inputs in the network; (iii) the time delay; and (iv) the firing frequency. Neuronal models such as Hodgkin-Huxley and adaptive exponential integrate-and-fire, among others, can be conveniently used in this study. (AU