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Synaptic plasticity in neuronal networks

Grant number: 20/04624-2
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): May 01, 2020
Effective date (End): September 30, 2024
Field of knowledge:Physical Sciences and Mathematics - Physics
Principal Investigator:Iberê Luiz Caldas
Grantee:Paulo Ricardo Protachevicz
Host Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:18/03211-6 - Non linear dynamics, AP.TEM
Associated scholarship(s):22/05153-9 - Neuronal networks with short-term plasticity, BE.EP.PD


In this project will be investigated the influence of synaptic plasticity to obtain synchronous and asynchronous firing patterns. The proposal foresee study of long and short term plasticity, evaluated for individual and conjoint case. Although these two types of plasticity act at the same time, the influence of each one occurs at different time scales. This study is justified due to the fact that abnormal synchronized states of activities are directly related to several neurological diseases such as Parkinson's Disease and Epilepsy. Otherwise, normal firing patterns of synchronization have been identified as a fact that benefits the formation of memories. Thus, to evaluate the effect of plasticity, we will have the dynamics of neuronal network also studied under the influence of factors such as (i) the network topology; (ii) the external signal inputs in the network; (iii) the time delay; and (iv) the firing frequency. Neuronal models such as Hodgkin-Huxley and adaptive exponential integrate-and-fire, among others, can be conveniently used in this study. (AU

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
TROBIA, JOSE; TIAN, KUN; BATISTA, ANTONIO M.; GREBOGI, CELSO; REN, HAI-PENG; SANTOS, MOISES S.; PROTACHEVICZ, PAULO R.; BORGES, FERNANDO S.; SZEZECH, JR., JOSE D.; VIANA, RICARDO L.; et al. Mathematical model of brain tumour growth with drug resistance. COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION, v. 103, . (18/03211-6, 20/04624-2, 17/18977-1, 15/07311-7)
LAMEU, EWANDSON L.; BORGES, FERNANDO S.; LAROSZ, KELLY C.; PROTACHEVICZ, PAULO R.; ANTONOPOULOS, CHRIS G.; MACAU, ELBERT E. N.; BATISTA, ANTONIO M.. Short-term and spike-timing-dependent plasticity facilitate the formation of modular neural networks. COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION, v. 96, . (15/50122-0, 17/13502-5, 16/23398-8, 15/07311-7, 17/18977-1, 17/20920-8, 20/04624-2, 11/19296-1)
PROTACHEVICZ, PAULO R.; IAROSZ, KELLY C.; CALDAS, IBERE L.; ANTONOPOULOS, CHRIS G.; BATISTA, ANTONIO M.; KURTHS, JURGEN. Influence of Autapses on Synchronization in Neural Networks With Chemical Synapses. FRONTIERS IN SYSTEMS NEUROSCIENCE, v. 14, . (15/50122-0, 20/04624-2)
PROTACHEVICZ, PAULO R.; HANSEN, MATHEUS; IAROSZ, KELLY C.; CALDAS, IBERE L.; BATISTA, ANTONIO M.; KURTHS, JURGEN. Emergence of Neuronal Synchronisation in Coupled Areas. FRONTIERS IN COMPUTATIONAL NEUROSCIENCE, v. 15, . (19/09150-1, 20/04624-2, 15/50122-0, 18/03211-6)
PALUDO SILVEIRA, JOAO ANTONIO; PROTACHEVICZ, PAULO RICARDO; VIANA, RICARDO LUIZ; BATISTA, ANTONIO MARCOS. Effects of burst-timing-dependent plasticity on synchronous behaviour in neuronal network. Neurocomputing, v. 436, p. 126-135, . (20/04624-2)

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