Evaluation of anti-inflammatory potential of kaempferide in paw edema and toxicological profile

• Grant number: 19/25979-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2020
• End date: February 28, 2021
• Field of knowledge: Biological Sciences - Pharmacology - Ethnopharmacology
• Principal Investigator: Ricardo Andrade Furtado
• Grantee: Danielle Vieira Pereira
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
• Associated research grant: 17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector, AP.TEM

Abstract

The Brazilian Green Propolis, produced by Apis meliferas bees, is used in the animal world to protect the hive. With activities described in the scientific literature and widely used in folk medicine, propolis has been the objective of pharmacological studies in the last 30 years and its composition is of high complexity being a mixture formed by resinous and balsamic material, depending on the flora of each region. Kaempferide is a compound present in Brazilian green propolis and it has biological activity, such as antiviral, antibacterial, antioxidant and gastroprotective. Given the biological activity of propolis and kaempferide, this study aims to evaluated the anti-inflammatory and toxicological potential of Kaempferide. To this end, the anti-inflammatory potential will be evaluated by the carrageenan-induced paw edema assay and histological evaluation of inflammatory processes by hematoxylin and eosin (HE), nephrotoxic activity by urea and creatinine dosages, and hepatotoxic by ALT and AST dosages. Thus this work aims to contribute to the understanding of the potential of this compound and green propolis, collaborating with the valorization of this national product as foreseen in the thematic proposal 2017/04138-8. (AU)