| Grant number: | 20/02413-4 |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| Start date: | April 01, 2020 |
| End date: | April 30, 2025 |
| Field of knowledge: | Biological Sciences - Biochemistry - Molecular Biology |
| Principal Investigator: | Pedro Alexandre Favoretto Galante |
| Grantee: | Rafael Luiz Vieira Mercuri |
| Host Institution: | Hospital Sírio-Libanês. Sociedade Beneficente de Senhoras (SBSHSL). São Paulo , SP, Brazil |
| Associated research grant: | 18/15579-8 - Retroelements: a driving force generating genetic novelties in the human and mouse genome, AP.JP2 |
| Associated scholarship(s): | 23/11391-2 - Combining full length transcription and bioinformatics pipelines to unravel the functional potential and improving annotation of retrocopies using a human population-scale dataset., BE.EP.DD |
Abstract Retrocopies of coding genes have been classified as processed and non-functional pseudogenes. Nowadays, it has been revealed that gene duplication intermediated by RNAs, the mechanism which generates retrocopies, holds a relevant role in the origin of novel genes in humans and other species. However, these studies are limited to specific examples and comprehensive analyses of the functional role of retrocopies are rare. Humans and mice have a similar number of retrocopies, 7500 on average, but few of the retrocopies are shared (less than 1%). Identifying the retrocopies fixed and, later, transcribed in these two species is extremely important. (AU) | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
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