Clinical and epidemiological study of SARS-CoV-2 in a prospective population and hospitalar cohorts in SJ Rio Preto, SP, Brazil in 2020

• Grant number: 20/07419-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2020
• End date: March 31, 2023
• Field of knowledge: Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
• Principal Investigator: Maurício Lacerda Nogueira
• Grantee: Guilherme Rodrigues Fernandes Campos
• Host Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil
• Associated research grant: 20/04836-0 - Clinical and epidemiological study of SARS-CoV-2 in a prospective population and hospitalar cohorts in São José do Rio Preto, SP, Brazil in 2020, AP.R

Abstract

In a global context COVID-19 is the biggest health threat in the present days, because, in just over four months, the SARS-CoV-2 has spread to 171 countries reaching a pandemic status. Most patients with COVID-19 have a mild course of the disease, however, approximately 20% develop severe disease with a high mortality rate that is associated with age, comorbidities, and immunosuppression. Epidemiological studies are used to reveal the extent of viral spread in homes, communities, and hospitals. Thus, preventive and control measures can be established by the authorities. This project proposes to use a pre-established population cohort containing four years of data collection on the participants. The cohort is carried out in a restricted neighborhood in the municipality of São José do Rio Preto, located in the Northwest region of the State of São Paulo. To this end, active participants in this study will be monitored for the appearance of symptoms related to COVID-19. A quick-access telephone number to the team will be made available in case of acute symptoms and, if necessary, referral to the local health service. Monitoring of hospitalized patients at the Hospital de Base of the Faculty of Medicine of São José do Rio Preto (FAMERP), who are suspected or confirmed by COVID-19, will also be carried out. Samples will be collected for further analysis of pro-inflammatory cytokines, possible biological markers that indicate worsening of the disease. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BITTAR, CINTIA; POSSEBON, FABIO SOSSAI; ULLMANN, LEILA SABRINA; GERALDINI, DAYLA BOTT; DA COSTA, VIVALDO G.; DE ALMEIDA, LUIZ G. P.; SANCHES, PAULO RICARDO DA S.; NASCIMENTO-JUNIOR, NAILTON M.; CILLI, EDUARDO M.; BANHO, CECILIA ARTICO; et al. The Emergence of the New P.4 Lineage of SARS-CoV-2 With Spike L452R Mutation in Brazil. FRONTIERS IN PUBLIC HEALTH, v. 9, OCT 1 2021. (20/07419-0, 20/04836-0)

BANHO, CECILIA ARTICO; SACCHETTO, LIVIA; FERNANDES CAMPOS, GUILHERME RODRIGUES; BITTAR, CINTIA; POSSEBON, FABIO SOSSAI; ULLMANN, LEILA SABRINA; MARQUES, BEATRIZ DE CARVALHO; DUTRA DA SILVA, GISLAINE CESLESTINO; MORAES, MARILIA MAZZI; PEREIRA PARRA, MAISA CARLA; et al. Impact of SARS-CoV-2 Gamma lineage introduction and COVID-19 vaccination on the epidemiological landscape of a Brazilian city. COMMUNICATIONS MEDICINE, v. 2, n. 1, p. 11-pg., 2022-07-22. (20/07419-0, 20/04836-0)

DA COSTA, VIVALDO GOMES; GOMES, ANA JULIA CHAVES; BITTAR, CINTIA; GERALDINI, DAYLA BOTT; DA CONCEICAO, PAMELA JOYCE PREVIDELLI; CABRAL, AGATA SILVA; CARVALHO, TAMARA; BISELLI, JOICE MATOS; PROVAZZI, PAOLA JOCELAN SCARIN; CAMPOS, GUILHERME RODRIGUES FERNANDES; et al. Burden of Influenza and Respiratory Syncytial Viruses in Suspected COVID-19 Patients: A Cross-Sectional and Meta-Analysis Study. Viruses-Basel, v. 15, n. 3, p. 16-pg., 2023-03-01. (20/07419-0, 19/18581-6, 21/00603-3)

COSTA, GUILHERME M. J.; LACERDA, SAMYRA M. S. N.; FIGUEIREDO, ANDRE F. A.; WNUK, NATALIA T.; BRENER, MARCOS R. G.; ANDRADE, LIDIA M.; CAMPOLINA-SILVA, GABRIEL H.; KAUFFMANN-ZEH, ANDREA; PACIFICO, LUCILA G. G.; VERSIANI, ALICE F.; et al. High SARS-CoV-2 tropism and activation of immune cells in the testes of non-vaccinated deceased COVID-19 patients. BMC Biology, v. 21, n. 1, p. 24-pg., 2023-02-16. (20/07419-0, 18/17647-0, 20/04836-0, 19/07250-9)

GRENFELL, RAFAELLA F. Q.; ALMEIDA, NATHALIE B. F.; FILGUEIRAS, PRISCILLA S.; CORSINI, CAMILA A.; GOMES, SARAH V. C.; DE MIRANDA, DANIEL A. P.; LOURENCO, ADELINA J.; MARTINS-FILHO, OLINDO A.; DE OLIVEIRA, JAQUELLINE G.; TEIXEIRA-CARVALHO, ANDREA; et al. Immunogenicity, Effectiveness, and Safety of Inactivated Virus (CoronaVac) Vaccine in a Two-Dose Primary Protocol and BNT162b2 Heterologous Booster in Brazil (Immunita-001): A One Year Period Follow Up Phase 4 Study. FRONTIERS IN IMMUNOLOGY, v. 13, p. 13-pg., 2022-06-09. (20/07419-0)

CAMPOS, GUILHERME R. F.; ALMEIDA, NATHALIE BONATTI FRANCO; FILGUEIRAS, PRISCILLA SOARES; CORSINI, CAMILA AMORMINO; GOMES, SARAH VIEIRA CONTIN; DE MIRANDA, DANIEL ALVIM PENA; DE ASSIS, JESSICA VIEIRA; SILVA, THAIS BARBARA DE SOUZA; ALVES, PEDRO AUGUSTO; FERNANDES, GABRIEL DA ROCHA; et al. Booster dose of BNT162b2 after two doses of CoronaVac improves neutralization of SARS-CoV-2 Omicron variant. COMMUNICATIONS MEDICINE, v. 2, n. 1, p. 4-pg., 2022-07-22. (20/07419-0, 20/04836-0)