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Clinical and epidemiological study of SARS-CoV-2 in a prospective population and hospitalar cohorts in SJ Rio Preto, SP, Brazil in 2020

Grant number: 20/07419-0
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): August 01, 2020
Effective date (End): March 31, 2022
Field of knowledge:Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
Principal Investigator:Maurício Lacerda Nogueira
Grantee:Guilherme Rodrigues Fernandes Campos
Home Institution: Faculdade de Medicina de São José do Rio Preto (FAMERP). Secretaria de Desenvolvimento Econômico (São Paulo - Estado). São José do Rio Preto , SP, Brazil
Associated research grant:20/04836-0 - Clinical and epidemiological study of SARS-CoV-2 in a prospective population and hospitalar cohorts in São José do Rio Preto, SP, Brazil in 2020, AP.R

Abstract

In a global context COVID-19 is the biggest health threat in the present days, because, in just over four months, the SARS-CoV-2 has spread to 171 countries reaching a pandemic status. Most patients with COVID-19 have a mild course of the disease, however, approximately 20% develop severe disease with a high mortality rate that is associated with age, comorbidities, and immunosuppression. Epidemiological studies are used to reveal the extent of viral spread in homes, communities, and hospitals. Thus, preventive and control measures can be established by the authorities. This project proposes to use a pre-established population cohort containing four years of data collection on the participants. The cohort is carried out in a restricted neighborhood in the municipality of São José do Rio Preto, located in the Northwest region of the State of São Paulo. To this end, active participants in this study will be monitored for the appearance of symptoms related to COVID-19. A quick-access telephone number to the team will be made available in case of acute symptoms and, if necessary, referral to the local health service. Monitoring of hospitalized patients at the Hospital de Base of the Faculty of Medicine of São José do Rio Preto (FAMERP), who are suspected or confirmed by COVID-19, will also be carried out. Samples will be collected for further analysis of pro-inflammatory cytokines, possible biological markers that indicate worsening of the disease. (AU)