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Evaluation of the mechanisms of action of Bacillus thuringiensis (Bacillales: Bacillaceae) encapsulated in polymeric microparticles

Grant number: 20/12779-6
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): May 01, 2021
Effective date (End): April 30, 2022
Field of knowledge:Agronomical Sciences - Agronomy - Plant Health
Principal researcher:Ricardo Antonio Polanczyk
Grantee:Jhones Luiz de Oliveira
Supervisor abroad: Alejandra Bravo
Home Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Research place: Universidad Nacional Autónoma de México, Morelos (UNAM), Mexico  
Associated to the scholarship:18/21142-1 - Encapsulation of Bacillus thuringiensis (Bacillales: Bacillaceae) in polymeric microparticles and association with nanoencapsulated chemical agent: evaluation of biological activity and mechanisms of action, BP.PD

Abstract

Bacillus thuringiensis (Bt) bacteria have been recognized for their high potential in the control of various agricultural pests. Recently, there has been multiple advances in both, the research and the market of novel insecticidal products, involving this biological agent. Developments in micro/nanotechnology have opened new perspectives for the production of more efficient formulations that can overcome some obstacles associated with the use of Bt-products in the field, such as formulation instability and loss of activity due to the degradation of toxins by their exposure to ultraviolet radiation, among other problems. The present proposal will explore the efficiency and mechanism of action of Bt-products based on micro/nanotechnology formulations. Several strategies will be addressed in order to assess the influence of encapsulation on the action of Bt toxins, such as analysis of crystals solubilization and activation in the gastric juice of the larvae, as well as their biding to specific receptors. In addition, the damage caused by microencapsulated Bt in the larval intestinal epithelium will also be investigated in vivo.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ABRANTES, DANIELE CARVALHO; ROGERIO, CAROLINA BARBARA; DE OLIVEIRA, JHONES L.; CAMPOS, ESTEFANIA V. R.; DE ARAUJO, DANIELE RIBEIRO; PAMPANA, LAURINDO CESAR; DUARTE, MARCELO JOSE; VALADARES, GEORGIO FREESZ; FRACETO, LEONARDO FERNANDES. Development of a Mosquito Repellent Formulation Based on Nanostructured Lipid Carriers. FRONTIERS IN PHARMACOLOGY, v. 12, . (18/02404-5, 17/24402-1, 18/14734-0, 20/12779-6)
DE OLIVEIRA, JHONES L.; FRACETO, LEONARDO FERNANDES; BRAVO, ALEJANDRA; POLANCZYK, RICARDO ANTONIO. Encapsulation Strategies for Bacillus thuringiensis: From Now to the Future. Journal of Agricultural and Food Chemistry, v. 69, n. 16, p. 4564-4577, . (20/12779-6, 18/21142-1, 17/21004-5)

Please report errors in scientific publications list by writing to: cdi@fapesp.br.