Impact of maropitant administration at Stomach-36 acupuncture point on anesthetic and analgesic requirement in dogs undergoing ovariohysterectomy

• Grant number: 20/10793-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2020
• End date: November 30, 2021
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Renata Navarro Cassu
• Grantee: Daniel Espinhosa Vieira
• Host Institution: Pró-Reitoria de Pesquisa e Pós-Graduação. Universidade do Oeste Paulista (UNOESTE). Presidente Prudente , SP, Brazil

Abstract

The aim of this study is to evaluate the impact of maropitan administration at Stomach-36 (ST-36) acupuncture point on anesthetic and analgesic requirements compared to the subcutaneous administration in dogs undergoing ovariohysterectomy. After intramuscular sedation with dexmedetomidine (5 µg/kg) plus meperidine (5 mg/kg), the dogs will be distributed into three groups: GSC (n = 12): subcutaneous administration of maropitan (1 mg/kg); GAP (n=12): maropitan (1 mg/kg) administration bilaterally at ST-36 acupuncture point; GC (n=12): control group. Anesthesia will be induced with propofol dose effect and maintained with isoflurane/O2. Heart rate, respiratory rate, systolic arterial blood pressure, oxicapnografy, and end tidal isoflurane concentration will be evaluated during the surgery. Sedation and analgesic degrees will be assessed preoperatively and 24 hours after the tracheal extubation using sedation scoring, the Numerical Rating Scale and the short-form of the Glasgow Composite Pain Scale (CMPS-SF). Morphine (0.5 mg/kg IM) will be administered as rescue analgesia if CMPS-SF e 6/24. Numerical data will be submitted to analysis of variance followed by Tukey's test for parametric measures and Kruskall-Wallis with post-Dunn test for nonparametric measures (p <0.05).