Impact of cellular senescence in Obesity-induced cardiovascular and metabolic dysfunctions in female mice

• Grant number: 20/14289-6
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: April 01, 2021
• End date: February 28, 2026
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Gabriela Placoná Diniz
• Grantee: Tábatha de Oliveira Silva
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 23/02585-8 - Role of the senescence in obesity-induced cardiac hypertrophy and the influence of the microRNAs, BE.EP.DR

Abstract

Obesity is a major risk factor related to the development of metabolic and cardiovascular diseases. Recent studies indicate that Obesity accelerates aging by stimulating cellular senescence. Although senescent cells have important functions in several physiological processes, they have a highly active metabolism and a secretory profile associated with senescence (SASP) that influence the tissue microenvironment, which may compromise its function and affect the function of other tissues. Men have a higher risk of developing metabolic and cardiovascular diseases compared to women. However, obese women have a higher risk of cardiovascular and metabolic complications than obese men or thin women, suggesting that the protective effect exerted by estrogen in women is reduced in Obesity. Recent studies identified that obese mice exhibit increased cellular senescence in white adipose tissue and that depletion of senescent cells attenuated some metabolic and cardiovascular disorders associated with Obesity. However, the mechanisms involved in Obesity-induced metabolic and cardiovascular disorders in females remain largely unknown. In this sense, this study aims to evaluate the impact of cellular senescence in Obesity-related metabolic and cardiovascular disorders in female mice, as well as the role of white adipose tissue senescence in Obesity-induced cardiac hypertrophy. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA, TABATHA DE OLIVEIRA; LUNARDON, GUILHERME; LINO, CAROLINE A.; SILVA, AMANDA DE ALMEIDA; ZHANG, SHIJU; IRIGOYEN, MARIA CLAUDIA COSTA; LU, YAO WEI; MABLY, JOHN D.; BARRETO-CHAVES, MARIA LUIZA M.; WANG, DA-ZHI; et al. Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders. MOLECULAR METABOLISM, v. 91, p. 15-pg., 2024-11-27. (22/10060-0, 20/13211-3, 20/14289-6, 23/03444-9, 23/02585-8)