Characterization of fibroblasts and endothelial cells activity on wound healing in rats treated topically with red Brazilian propolis

• Grant number: 21/01258-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2021
• End date: December 31, 2022
• Field of knowledge: Health Sciences - Pharmacy - Pharmacognosy
• Principal Investigator: Claudia Helena Pellizzon
• Grantee: Mariana Conceição
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
• Associated research grant: 17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector, AP.TEM

Abstract

The wound healing process depends on many biochemical and physiological factors that trigger mediators to cellular activation and tissue reorganization. Depending on metabolic changes, wounds may take years to complete closure, and this results from the fact that there is no gold standard for effective skin wound healing. Thus, the search for a new product is necessary and red propolis has been seen with great interest for wound healing studies thanks to its composition, rich in phenolic compounds such as isoflavonoids and terpenes, possibly the main responsible for anti-inflammatory, immunomodulatory, antioxidant and antitumor properties already cited in the literature. Therefore, formulations based on red Brazilian propolis will be administered topically on second-intention injuries in rats during 3, 7 and 14 days of treatment to evaluate fibroblast and endothelial cells alteration, mechanotransduction and angiogenesis by histological, immunohistochemical and molecular biology methods. This work is linked to the thematic project, approved by FAPESP (FAPESP: 2017/04138-8).

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CONCEICAO, MARIANA; SERGIO GUSHIKEN, LUCAS FERNANDO; ALDANA-MEJIA, JENNYFER ANDREA; TANIMOTO, MATHEUS HIKARU; DE SA FERREIRA, MARCOS VITAL; MIRANDA ALVES, ANDREIA CRISTINA; MIYASHITA, MARINA NAOMI; BASTOS, JAIRO KENUPP; BESERRA, FERNANDO PEREIRA; PELLIZZON, CLAUDIA HELENA. Histological, Immunohistochemical and Antioxidant Analysis of Skin Wound Healing Influenced by the Topical Application of Brazilian Red Propolis. ANTIOXIDANTS, v. 11, n. 11, p. 20-pg., 2022-11-01. (21/01258-8, 17/04138-8)