Subarachnoid haemorrhage-in-a-chip

• Grant number: 21/14327-8
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Effective date (Start): May 01, 2022
• Status: Discontinued
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Marimélia Aparecida Porcionatto
• Grantee: Laura Nicoleti Zamproni
• Host Institution: Instituto Nacional de Farmacologia (INFAR). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated research grant: 18/12605-8 - Development of brain-on-a-chip microplataforms for in vitro modeling of the central nervous system, AP.TEM
• Associated scholarship(s): 22/16296-5 - Modeling heart-brain interactions-on-a-chip, BE.EP.PD

Abstract

Subarachnoid haemorrhage (SAH) is a stroke subtype with high mortality and social cost. Up to now, there are few or no specific therapy for the condition, which makes it urgent to identify new therapeutic targets. Astrocytes and endothelial cells are components of the blood-brain barrier (BBB) that have been described as protagonists in the complex pathophysiology of SAH, therefore likely to become new therapeutic targets. Our goal is to develop a microfluidic tridimensional in vitro model that can mimic the effects of subarachnoid hemorrhage on BBB cells to improve the understanding of the pathophysiological aspects of the disease and facilitate the identification of new metabolic pathways and biomarkers for diagnosis, prognosis and therapy.