Subarachnoid haemorrhage (SAH) is a stroke subtype with high mortality and social cost. Up to now, there are few or no specific therapy for the condition, which makes it urgent to identify new therapeutic targets. Astrocytes and endothelial cells are components of the blood-brain barrier (BBB) that have been described as protagonists in the complex pathophysiology of SAH, therefore likely to become new therapeutic targets. Our goal is to develop a microfluidic tridimensional in vitro model that can mimic the effects of subarachnoid hemorrhage on BBB cells to improve the understanding of the pathophysiological aspects of the disease and facilitate the identification of new metabolic pathways and biomarkers for diagnosis, prognosis and therapy.
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