Development and analysis of alumina scaffolds containing 5% zirconia (S-Al2O3/ZrO2) coated with calcium phosphate

• Grant number: 22/00590-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2022
• End date: May 31, 2023
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Silvio Henrique de Freitas
• Grantee: Pedro Hass Megale
• Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil

Abstract

Orthopedic conditions that require specialized surgical procedures for bone tissue replacement are frequent in both veterinary and human medicine. Therefore, it is not uncommon for surgeons to face long bone fractures, bone neoplasms or fracture non-unions, which require reparative surgical treatment with the use of bone substitutes. The aim of this research is to develop alumina scaffolds containing 5% zirconia (S-Al2O3/ZrO2) coated with calcium phosphate for twenty-one days (21d) and analyze them by scanning electron microscopy (SEM), stereomicroscopy and cytotoxicity assay. It is expected that S-Al2O3/ZrO2 (21d) have potential for clinical application and can be used as an alternative in the repair of orthopedic injuries with bone loss, with satisfactory results, low cost, easy acquisition and access, improving the patient's quality of life. (AU)