Assessment of functional yoghurt efficacy to decrease the toxic effects of aflatoxins alone or in combination with fumonisins on piglets

• Grant number: 22/05066-9
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: June 01, 2022
• End date: October 31, 2025
• Field of knowledge: Agronomical Sciences - Food Science and Technology
• Principal Investigator: Carlos Augusto Fernandes de Oliveira
• Grantee: Lucas Gabriel Dionisio Freire
• Host Institution: Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil
• Associated research grant: 19/21603-1 - Biomarker approaches for assessing the early life exposure to multiple mycotoxins in the diet, AP.TEM
• Associated scholarship(s): 24/03289-6 - ASSESSMENT OF FUMONISIN REMOVAL BY STRAINS OF LACTIC ACID BACTERIA AND YEASTS, BE.EP.DD

Abstract

Mycotoxins are secondary metabolites produced by fungi that occur naturally in foodstuffs, which can cause a large variety of toxic effects on vertebrates, including humans. There is evidence that mycotoxin bioavailability can be modulated by Lactic Acid Bacteria (LAB) and yeast biomass, thus reducing the dietary exposure to aflatoxins. The objective of this project is to assess the efficacy of a functional yoghurt previously prepared with LAB and yeasts biomass (0 e 4%), to decrease the toxic effects of aflatoxins (0 and 1.0 mg/kg) in feed, alone or in combination with fumonisins (0 and 10 mg/kg), on piglets, during 28 days. Data on performance, histology, serum biochemistry parameters and serum mycotoxin biomarkers will be analyzed as a 2 x 2 x 2 factorial. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FREIRE, LUCAS GABRIEL DIONISIO; ALI, SHER; DE OLIVEIRA, CARLOS AUGUSTO FERNANDES. Evaluation of Adsorbent's Efficiency by Using Biomarker Approaches in Farm Animals: A Systematic Review. APPLIED SCIENCES-BASEL, v. 12, n. 24, p. 13-pg., 2022-12-01. (19/21603-1, 22/05066-9, 22/03952-1)

FREIRE, LUCAS GABRIEL DIONISIO; ALI, SHER; DE OLIVEIRA, CARLOS AUGUSTO FERNANDES. Effectiveness of biological decontamination methods to reduce the toxic effects of mycotoxins in animal models: a review. Toxin Reviews, v. 43, n. 4, p. 19-pg., 2024-06-25. (22/03952-1, 19/21603-1, 22/05066-9)

ALI, SHER; FREIRE, LUCAS GABRIEL DIONISIO; REZENDE, VANESSA THEODORO; NOMAN, MUHAMMAD; ULLAH, SANA; ABDULLAH; BADSHAH, GUL; AFRIDI, MUHAMMAD SIDDIQUE; TONIN, FERNANDO GUSTAVO; DE OLIVEIRA, CARLOS AUGUSTO FERNANDES. Occurrence of Mycotoxins in Foods: Unraveling the Knowledge Gaps on Their Persistence in Food Production Systems. FOODS, v. 12, n. 23, p. 17-pg., 2023-12-01. (22/03952-1, 22/05066-9, 23/05989-2)

ALI, SHER; FRANCO, BRUNA BATTAGLINI; REZENDE, VANESSA THEODORO; FREIRE, LUCAS GABRIEL DIONISIO; DE PAIVA, ESTHER LIMA; HAIKAL, MARIA CLARA FOGACIO; GUERRA, ELOIZA LEME; ROSIM, ROICE ELIANA; TONIN, FERNANDO GUSTAVO; FERRAZ, IVAN SAVIOLI; et al. Exposure assessment of children to dietary mycotoxins: A pilot study conducted in Ribeirao Preto, Sao Paulo, Brazil. Food Research International, v. 180, p. 9-pg., 2024-02-09. (22/03952-1, 22/05066-9)