Analysis of the effect of soluble polysaccharides extracted from wheat bran on Colon Cancer cells lines

• Grant number: 21/11688-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2022
• End date: January 31, 2023
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Science
• Principal Investigator: Joao Paulo Fabi
• Grantee: Candela Paesani
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 13/07914-8 - FoRC - Food Research Center, AP.CEPID

Abstract

Wheat bran is the layer where most of the dietary fiber and minerals in the grain are found. However, it is discarded in the milling process to obtain wheat flour. Despite the richness of polysaccharides in bran, extraction is often uninteresting and costly for the food industry. Colon Cancer is one of the most common cancers worldwide and both diet and lifestyle have been shown to play a key role in the development of the disease. Several studies have shown that soluble polysaccharides have beneficial effects in mitigating Colon Cancer emergence and growth. The aim of this work is to extract soluble polysaccharides from discarded wheat bran in an inexpensive way, analyze their physic-chemical structure and evaluate their anticancer effects against Colon Cancer cell lines in 2D and 3D cultures. (AU)