Effect of botulinum toxin A in an animal model for incisional hernia

• Grant number: 22/05651-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2022
• End date: January 31, 2023
• Field of knowledge: Health Sciences - Medicine - Surgery
• Principal Investigator: Francisco Tustumi
• Grantee: Eric Toshiyuki Nakamura
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Introduction: Incisional hernias occur when the tissue around an abdominal laparotomy fails to regenerate properly. Objective: The objective of the present study is to demonstrate in an animal model the potential of botulinum toxin type A in preventing recurrence of incisional hernia through paralysis of the abdominal muscles and reduction of intra-abdominal pressure. Methods: Twenty Wistar rats will be analyzed. The animals will be divided into two groups (1:1). Group 1: Control group. Animal models of incisional hernia will receive saline in the abdominal wall musculature. Group 2: Animal models of incisional hernia will receive botulinum toxin type A in the abdominal wall. The outcomes evaluated will be: hernia recurrence, macroscopic appearance, histological and immunohistochemical analysis to assess tissue regeneration.