Effect of diet with different sources of acids fat on the abundance and gene expression of cytokines in a model animal

• Grant number: 21/10394-2
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): August 01, 2022
• Effective date (End): March 01, 2024
• Field of knowledge: Agronomical Sciences - Animal Husbandry - Genetics and Improvement of Domestic Animals
• Principal Investigator: Aline Silva Mello Cesar
• Grantee: Fernanda Nery Ciconello
• Host Institution: Escola Superior de Agricultura Luiz de Queiroz (ESALQ). Universidade de São Paulo (USP). Piracicaba , SP, Brazil
• Associated research grant: 17/25180-2 - Effect of dietary oleic acid on fatty acid composition and inflammatory response profile in different tissues of pigs, AP.JP
• Associated scholarship(s): 22/13606-3 - Effect of diet with different fatty acid sources related to cytokines abundance and gene expression in model animal, BE.EP.MS

Abstract

Fatty acids have structural, endocrine and energy functions for the cells of the pigs. The types of fatty acids, administration time, sex and species are variables that can influence the fatty acid composition in the inflammatory cells membranes of pigs. Lipid metabolism can be regulated by the liver, skeletal muscle and adipose tissue, and these lipids are used in beta-oxidation. Some fatty acids, such as omega three and six, are not synthesized by the pigs and they must be supplemented in the diet. In this case, the relation between omega six and omega three can influence the metabolism of animals and their inflammatory response through the production of cytokines. Diets supplemented with omega three can increase cytokine synthesis in liver and adipose tissue. Some transcription factors related to lipid metabolism can up-regulate or down-regulate the cytokine synthesis in the tissues. In the same way that cytokines can interfere with gastrointestinal absorption and intramuscular fat deposition. The aim of this project will be to evaluate the presence of cytokines in muscle, liver and nervous tissues of pigs under different dietary sources of fatty acids through the multiplex ELISA technique. (AU)