EVALUATION OF ENERGY EXPENDITURE AND MODULATION OF PLASTICITY OF ADIPOSE TISSUE INDUCED BY CONSUMPTION OF INTERESTERIFIED OR PARTIALLY HYDROGENATED FAT IN MICE.

• Grant number: 22/09707-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2022
• End date: December 25, 2024
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Marciane Milanski Ferreira
• Grantee: João Víctor da Silva Domingues
• Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
• Associated research grant: 13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID
• Associated scholarship(s): 23/12761-8 - Effects of interesterified fat metabolites on thermogenic function on human adipocyte cell line, BE.EP.IC

Abstract

Lipids are essential for the human body, participating in important functions such as energy storage, cell signaling, formation of steroid hormones, cell structures and other functions essential to life. However, fats have been excessively used in the contemporary diet, especially in processed and ultra-processed industrialized products, whose consumption is associated with metabolic disorders, such as obesity, type II diabetes, atherosclerosis, metabolic syndrome and other chronic diseases that are involved in this context. Several experimental and epidemiological studies have already shown that the consumption of trans fat, which was present in industrialized products, is positively associated with the incidence of cardiovascular diseases. Considering this, the food industry started to use interesterified fat as an alternative for food production. However, knowlodge is limited about the effects of interesterified fat on metabolism and body homeostasis. Therefore, this work seeks to understand and analyze whether the consumption of interesterified fat, so present today, could influence body mass gain, the thermogenesis process and the plasticity of adipose tissue in mice fed normolipid diets containing interesterified soybean oil or partially hydrogenated (rich in trans isomers).