In vitro study of human intestinal integrity and TLR modulation after modified passion fruit pectin treatment

• Grant number: 22/12253-0
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
• Start date: June 01, 2023
• End date: May 31, 2024
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Science
• Principal Investigator: Joao Paulo Fabi
• Grantee: Lucas de Freitas Pedrosa
• Supervisor: Paulus de Vos
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Institution abroad: University of Groningen, Netherlands
• Associated to the scholarship: 20/08063-5 - Study of the biological effects of modified passion fruit pectins using in vitro and in vivo models of Colon Carcinogenesis, BP.DD

Abstract

Some plant-derived polysaccharides present immunomodulatory potential. A proinflammatory environment can aggravate colorectal cancer pathogenesis and progression. Pectins have been studied in this regard as protector molecules. One of the most promising results in this area is the interaction between different pectic epitopes and varied Toll-like receptors. The capacity of restoring intestinal barrier disruptive scenarios has also been explored with those molecules. The pattern of the methyl-esterification appearance throughout the molecule is one of the hypothesized and explored aspects to those beneficial biological effects observed. Many different pectin sources have been studied, however passion fruit has not gone through this type of analysis before. Therefore, the application of passion fruit pectin, both native and thermally modified, is a major topic of interest. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PEDROSA, LUCAS DE FREITAS; NASCIMENTO, KAREN REBOUCAS; SOARES, CAROLINE GIACOMELLI; DE OLIVEIRA, DEBORA PRECELIANO; DE VOS, PAUL; FABI, JOAO PAULO. Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure. PLANTS-BASEL, v. 12, n. 14, p. 21-pg., 2023-07-01. (22/12834-2, 20/08063-5, 22/12253-0, 13/07914-8)