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Salmonella enterica and Cronobacter sakazakii: both pathogens of powdered infant formula: an omic compartive study to understand their behavior along the food production chain

Grant number: 22/14938-0
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Start date: May 01, 2023
End date: April 30, 2024
Field of knowledge:Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
Principal Investigator:Anderson de Souza Sant'Ana
Grantee:Emilie Lang
Supervisor: Min Suk Rhee
Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Institution abroad: Korea University (KU), South Korea  
Associated to the scholarship:19/16209-2 - Salmonella and Cronobacter sakazakii in milk and infant formula: behavior during spray drying and determination of inactivation parameters based on single droplet approach, BP.PD

Abstract

Food safety is key for food industry and protection of public health. Nevertheless, the increasing of the food chain complexity induces a more and more variety of outbreaks even in well managed environment. Some of ingredients are especially critical for food safety as they are in the center of other production chains. For example, milk powder is necessary for numerous transformed food products and especially for powdered infant formula, which is a food intended for the consumption by sensitive populations. Powdered infant formula and milk powder are associated with outbreaks involving Salmonella enterica and Cronobacter sakazakii. These two bacteria are particularly known to be highly resistant to dry environment but also, they show a high diverse behavior as a response to stresses. This fact shows that complexes and diverse mechanisms play a role in the survival of these microorganisms. It is in this perspective that a study of the full genome of 15 strains of each species (Salmonella enterica and Cronobacter sakazakii) with different levels of stress resistance will be critical to understand this variability. In the same way, a transcriptomic analysis will be key to understand the difference of gene expression among the strains. Altogether, these findings will globally assist to gain insights about the different acclimation and adaptation footprint of these two main pathogens of the milk powder industry. These findings will assist in the development/optimization of more efficient intervention strategies to fight efficiently against Salmonella enterica and Cronobacter sakazakii survival along the food chain. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LANG, EMILIE; RHEE, MIN SUK; GONCALVES, MARIA PAULA M. B. B.; SANT'ANA, ANDERSON S.. Desiccation strategies of Cronobacter sakazakii to survive in low moisture foods and environment. TRENDS IN FOOD SCIENCE & TECHNOLOGY, v. 143, p. 17-pg., . (22/14938-0, 19/16209-2)