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Functional analysis of C-terminal disordered regions (dCTRs) associated with lytic polysaccharide monooxygenases (LPMOs): biochemical characterization and assessment of potential roles in enzyme stability and electron transfer to the LPMO domain

Grant number: 23/09421-0
Support Opportunities:Scholarships abroad - Research Internship - Scientific Initiation
Effective date (Start): September 29, 2023
Effective date (End): January 28, 2024
Field of knowledge:Biological Sciences - Biochemistry - Enzymology
Principal Investigator:Fernando Segato
Grantee:Gabriel de Almeida Fozzati
Supervisor: Aniko Varnai
Host Institution: Escola de Engenharia de Lorena (EEL). Universidade de São Paulo (USP). Lorena , SP, Brazil
Research place: Norwegian University of Life Sciences (NMBU), Norway  
Associated to the scholarship:22/14376-1 - Functional analysis of disordered regions associated to lytic polysaccharide monooxygenases (LPMO): Biochemical characterization and interaction with cellobiose dehydrogenase (CDH), BP.IC


Lytic polysaccharide monooxygenases (LPMOs) are gaining importance in plant biomass valorization due to their ability to accelerate biomass saccharification to platform sugars and to create functional groups in cellulose fibers. As LPMOs are a relatively recent discovery, many of their characteristics remain unknown, including the role of enigmatic disordered C-terminal regions (dCTRs) that seem to be highly abundant in LPMOs. The current undergraduate research project focuses on investigating the hitherto unknown function of such a dCTR in AfAA9C, an LPMO from Aspergillus fumigatus. We will focus on elucidating its potential role in LPMO stability as well as in the LPMO's interaction with the redox partner enzyme CDH, regarding protein-protein interactions and electron transfer. The objective of this BEPE project is to investigate this interaction through various approaches in collaboration with Res. Prof. Aniko Varnai and Prof. Vincent Eijsink, whose group at the Norwegian University of Life Sciences is a pioneer in LPMO research. (AU)

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