Effects of interesterified fat metabolites on thermogenic function on human adipocyte cell line

• Grant number: 23/12761-8
• Support Opportunities: Scholarships abroad - Research Internship - Scientific Initiation
• Start date: January 01, 2024
• End date: April 25, 2024
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Marciane Milanski Ferreira
• Grantee: João Víctor da Silva Domingues
• Supervisor: Francesc Villarroya
• Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
• Institution abroad: Universitat de Barcelona (UB), Spain
• Associated to the scholarship: 22/09707-9 - EVALUATION OF ENERGY EXPENDITURE AND MODULATION OF PLASTICITY OF ADIPOSE TISSUE INDUCED BY CONSUMPTION OF INTERESTERIFIED OR PARTIALLY HYDROGENATED FAT IN MICE., BP.IC

Abstract

The food industry used to benefit from the process known as partial hydrogenation of vegetable oils and fats to produce trans fatty acids, thus giving processed and ultra-processed food desirable characteristics such as: oxidative stability, lower cost and higher sensorial value. Conversely, the use of trans-fat was widely related to cardiovascular disease and mortality worldwide, leading to a major public health concern and subsequential actions to reduce trans-fat over diet. To overcome the diminished use of partial hydrogenation, food industry them adopted the interesterification process, that could grant desirable properties previous found in trans-fat. Interesterified fat (IF) is achieved by rearranging fatty acids in the glycerol backbone of a triacylglycerol molecule, thus granting a semi solid characteristic and higher stability without changing saturation degree. Unlike trans-fat, IF does not have as many studies that elucidate its role in metabolism and numerous are debatable regarding the outcomes from IF consumption. Recently, it was demonstrated that IF consumption can impact glucose homeostasis, higher inflammatory profile in liver, adipose tissue and intestine, disrupt hepatic metabolism, lead to increased intestinal permeability and promote ceramide synthesis. Therefore, this project targets to comprehend metabolic and thermogenic molecular mechanisms in human adipocyte cell line exposed to interesterified monoacylglycerol (2-palmitoil glycerol, 2-PG) or Palmitate (Palm). (AU)