Synthesis of Ru(II)-oxazoline complexes and application in C-H functionalization.

• Grant number: 23/11514-7
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: January 01, 2024
• Status: Discontinued
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Caio Costa Oliveira
• Grantee: Erick Martins de Carvalho Pinheiro
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 24/20683-0 - Asymmetric "Homo"-Cross Coupling merging Electrochemistry with Transition-Metal Catalysis, BE.EP.DD

Abstract

RuCl2(p-cymene)]2 catalyst is the more widely employed ruthenium source in C-H functionalization. Recently, ruthenacycles were reported as efficient catalyst foralkylation and arylation reactions under mild conditions In both cases, catalyticsystems provide non chiral products.Herein, we aim to develop a methodology of enantioselective C-H activationcatalyzed by ruthenium . For this new ruthenium complexes were synthesized andessayed towards C-H activation.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PINHEIRO, ERICK M. C.; COUTO, DANIEL P.; OLIVEIRA, CAIO C.. Ru(II)-catalyzed ortho C-H Arylation of Heterocyclic Biaryls. ASIAN JOURNAL OF ORGANIC CHEMISTRY, v. N/A, p. 5-pg., 2024-11-23. (20/12435-5, 23/11514-7, 18/01669-5)

BRANDAO-TELES, CAROLINE; CARREGARI, VICTOR CORASOLLA; REIS-DE-OLIVEIRA, GUILHERME; SMITH, BRADLEY J.; CHAVES, YANE; SOUSA SANTOS, ALINE VALERIA; PINHEIRO, ERICK MARTINS DE CARVALHO; OLIVEIRA, CAIO C.; VIEIRA, ANDRE SCHWAMBACH; CRUNFLI, FERNANDA; et al. Impacts of hnRNP A1 Splicing Inhibition on the Brain Remyelination Proteome. Journal of Neurochemistry, v. 169, n. 1, p. 16-pg., 2025-01-01. (19/22398-2, 17/25588-1, 18/01669-5, 23/08885-3, 18/01410-1, 19/05155-9, 23/11514-7)